A golgi analysis of cortical pyramidal cells in the unilateral parkinson rat: absence of change in the affected hemisphere vs hypertrophy in the intact hemisphere.

A golgi analysis of cortical pyramidal cells in the unilateral parkinson rat: absence of change in the affected hemisphere vs hypertrophy in the intact hemisphere. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

A golgi analysis of cortical pyramidal cells in the unilateral parkinson rat: absence of change in the affected hemisphere vs hypertrophy in the intact hemisphere. Abstract Text:

Elena I Miklyaeva,Ian Q Whishaw,Bryan Kolb,

PURPOSE: Unilateral dopamine (DA) depletion in the rat provides an analog of human Parkinson's disease. The classic view of DA loss is that it produces changes in the activity of striatal-cortical circuitry that results in reduced frontal cortex neural activity. This "functional deafferent" view is consistent with findings that animals display sensorimotor deficits in the contralateral-to-lesion side of the body and compensatory behavior adjustments in the ipsilateral-to-lesion side of the body. The present study examined how DA depletion and the associated sensorimotor changes affect the morphology of the ipsilateral or contralateral neocortex neurons as assessed by dendritic morphology in Golgi-stained tissue. METHOD: Rats were given unilateral 6-hydroxydopamine (6-OHDA) or sham lesions in the nigrostriatal bundle. Lesion success was confirmed by enduring bilateral motor impairments in a skilled-reaching task, compensatory use of the ipsilateral-to-lesion limbs, and by increases in amphetamine and apomorphine-induced rotational behavior. RESULTS: Brains processed for Golgi-Cox staining at 1, 3, 8, or 24 months after the lesion showed no changes in dendritic arborization or synapse number in layer V pyramidal cells of motor cortex ipsilateral to the 6-OHDA lesion (DA-depleted hemisphere) at any postsurgical recovery stage. There was an increase in dendritic arborization in all lesion groups in the hemisphere contralateral to the lesion (good hemisphere). CONCLUSION: The results are inconsistent with the classical view of frontal cortex functional deafferentiation due to DA loss but do suggest that compensatory behavior leads to dendritic hypertrophy in the good hemisphere.

A golgi analysis of cortical pyramidal cells in the unilateral parkinson rat: absence of change in the affected hemisphere vs hypertrophy in the intact hemisphere. Publishing Authors By Initials

EI Miklyaeva,IQ Whishaw,B Kolb,

For similar nervous system: synapses research abstracts see: nervous system: synapses research

PUBMED ID PMID:

MEDLINE DATE:

A golgi analysis of cortical pyramidal cells in the unilateral parkinson rat: absence of change in the affected hemisphere vs hypertrophy in the intact hemisphere. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Restorative neurology and neuroscience

VOLUME: 25

Page Numbers: 91-9

Journal Abbreviation: Restor. Neurol. Neurosci.

ISSN: 0922-6028

DAY: 19

MONTH: 11

YEAR: 2007

A golgi analysis of cortical pyramidal cells in the unilateral parkinson rat: absence of change in the affected hemisphere vs hypertrophy in the intact hemisphere. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9005499

A golgi analysis of cortical pyramidal cells in the unilateral parkinson rat: absence of change in the affected hemisphere vs hypertrophy in the intact hemisphere. Keywords Mesh Terms:

KEYWORDS: Synapses

MESH TERMS: ultrastructure

Chemical & Substance for Abstract: A golgi analysis of cortical pyramidal cells in the unilateral parkinson rat: absence of change in the affected hemisphere vs hypertrophy in the intact hemisphere. Information

Substance Name: Apomorphine

Registry Number: 58-00-4

Grant and Affiliation Information for A golgi analysis of cortical pyramidal cells in the unilateral parkinson rat: absence of change in the affected hemisphere vs hypertrophy in the intact hemisphere.

AFFILIATION: Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, T1K 3M4, Canada.

Country: Netherlands

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Restor Neurol Neurosci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

A golgi analysis of cortical pyramidal cells in the unilateral parkinson rat: absence of change in the affected hemisphere vs hypertrophy in the intact hemisphere Related Publications

• A golgi analysis of cortical pyramidal cells in the unilateral parkinson rat: absence of change in the affected hemisphere vs hypertrophy in the intact hemisphere.
• Allogeneic bone marrow transplantation in leukemia.
• An evaluation of lobotomy and its potentialities for future research in psychiatry and the basic sciences.
• Animal models of pulmonary fibrosis: how far from effective reality?
• Chronic phencyclidine treatment increases dendritic spine density in prefrontal cortex and nucleus accumbens neurons.
• Classically conditioned withdrawal reflex in cerebellar patients. 1. Impaired conditioned responses.
• Comparison of the electrically evoked leg withdrawal reflex in cerebellar patients and healthy controls.
• Detection of changes in grip forces on a sliding object.
• ELECTROPHYSIOLOGICAL INVESTIGATIONS IN RETINAL METABOLIC DISEASE: THEIR RANGE AND APPLICATION.
• Eyeblink conditioning in patients with hereditary ataxia: a one-year follow-up study.
• Grouped comparisons of sleep quality for new and personal bedding systems.
• Neurophysiological properties of cells filling the neonatal medial prefrontal cortex lesion cavity.
• Potential-induced structure changes of oligopyridine adlayers on Au(111) electrodes.
• Preclinical analysis of tasidotin HCl in Ewing's sarcoma, rhabdomyosarcoma, synovial sarcoma, and osteosarcoma.
• Progressive pulmonary fibrosis is mediated by TGF-beta isoform 1 but not TGF-beta3.
• Responses of cerebellar units to a passive movement in the decerebrate cat.
• Secondary hyperparathyroidism and brown tumors in a patient with gluten enteropathy.
• Social instability blocks functional restitution following motor cortex stroke in rats.
• The bleomycin animal model: A useful tool to investigate treatment options for idiopathic pulmonary fibrosis?
• The posterior interosseous nerve syndrome.
• Three-dimensional computed tomography imaging in an animal model of emphysema.
• Use of soy protein isolate in slimming food.
• [Chances and risks of prevention in elderly people for the three major cancers: breast-, prostate- and colorectal cancers]
• [Diagnostic and treatment goals in elderly patients.]
• [Obliteration of the cervical canal following curettage.]
• [Perforation of the uterus with injury of the bladder during curettage for climacteric hemorrhage.]
• [Some characteristic moments from the work of the medical service of the partisan units in the southern Morava river basin during 1941-1943]
• [Some observations on taking the examination for captain and major in the medical service.]
• [Strategies for the avoidance and treatment of complications during pacemaker implantation.]
• [Various observations on the medical service in the army.]