A gold nanoparticle based approach for screening triplex DNA binders.

A gold nanoparticle based approach for screening triplex DNA binders. Research Abstract Details 

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A gold nanoparticle based approach for screening triplex DNA binders. Abstract Text:

Min Su Han,Abigail K R Lytton-Jean,Chad A Mirkin,

Nanoparticle assemblies interconnected with DNA triple helixes can be used to colorimetrically screen for triplex DNA binding molecules and simultaneously determine their relative binding affinities based on melting temperatures. Nanoparticles assemble only when DNA triple helixes form between DNA from two different particles and a third strand of free DNA. In addition, the triple helix structure is unstable at room temperature and only forms in the presence of triplex DNA binding molecules which stabilize the triple helix. The resulting melting transition of the nanoparticle assembly is much sharper and at a significantly higher Tm than the analogous triplex structure without nanoparticles. Upon nanoparticle assembly, a concomitant red-to-blue color change occurs. The assembly process and color change do not occur in the presence of duplex DNA binders and therefore provide a significantly better screening process for triplex DNA binding molecules compared to standard methods.

A gold nanoparticle based approach for screening triplex DNA binders. Publishing Authors By Initials

MS Han,AK Lytton-Jean,CA Mirkin,

For similar heterocyclic compounds: heterocyclic compounds, 1-ring: pyridines research abstracts see: heterocyclic compounds: heterocyclic compounds, 1-ring: pyridines research

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A gold nanoparticle based approach for screening triplex DNA binders. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of the American Chemical Society

VOLUME: 128

Page Numbers: 4954-5

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 19

MONTH: Apr

YEAR: 2006

A gold nanoparticle based approach for screening triplex DNA binders. Information

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LANGUAGE: eng

NlmUniqueID: 7503056

A gold nanoparticle based approach for screening triplex DNA binders. Keywords Mesh Terms:

KEYWORDS: Pyridines

MESH TERMS: chemistry

Chemical & Substance for Abstract: A gold nanoparticle based approach for screening triplex DNA binders. Information

Substance Name: DNA

Registry Number: 9007-49-2

Grant and Affiliation Information for A gold nanoparticle based approach for screening triplex DNA binders.

AFFILIATION: Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA.

Country: United States

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MEDLINETA: J Am Chem Soc

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