A glimpse into the active site of a group II intron and maybe the spliceosome, too.

A glimpse into the active site of a group II intron and maybe the spliceosome, too. Research Abstract Details 

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A glimpse into the active site of a group II intron and maybe the spliceosome, too. Abstract Text:

The X-ray crystal structure of an excised group II self-splicing intron was recently solved by the Pyle group. Here we review some of the notable features of this structure and what they may tell us about the catalytic active site of the group II ribozyme and potentially the spliceosome. The new structure validates the central role of domain V in both the structure and catalytic function of the ribozyme and resolves several outstanding puzzles raised by previous biochemical, genetic and structural studies. While lacking both exons as well as the cleavage sites and nucleophiles, the structure reveals how a network of tertiary interactions can position two divalent metal ions in a configuration that is ideal for catalysis.

A glimpse into the active site of a group II intron and maybe the spliceosome, too. Publishing Authors By Initials

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A glimpse into the active site of a group II intron and maybe the spliceosome, too. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: RNA (New York, N.Y.)

VOLUME: 14

Page Numbers: 1697-703

Journal Abbreviation: RNA

ISSN: 1469-9001

DAY: 24

MONTH: 07

YEAR: 2008

A glimpse into the active site of a group II intron and maybe the spliceosome, too. Information

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LANGUAGE: eng

NlmUniqueID: 9509184

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Grant and Affiliation Information for A glimpse into the active site of a group II intron and maybe the spliceosome, too.

AFFILIATION: Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM77326

ACRONYM: GM

MEDLINETA: RNA

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