A genome-wide set of congenic mouse strains derived from CAST/Ei on a C57BL/6 background.

A genome-wide set of congenic mouse strains derived from CAST/Ei on a C57BL/6 background. Research Abstract Details 

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A genome-wide set of congenic mouse strains derived from CAST/Ei on a C57BL/6 background. Abstract Text:

Richard C Davis,Angela Jin,Melenie Rosales,Suzanne Yu,Xiaoyu Xia,Kathleen Ranola,Eric E Schadt,Aldons J Lusis,

We previously reported the construction of two sets of heterozygous congenic strains spanning the mouse genome. For both sets, C57BL/6J was employed as the background strain while DNA from either DBA/2 or CAST/Ei was introgressed to form the congenic region. We have subsequently bred most of these strains to produce homozygous breeding stocks. Here, we report the characterization of the strain set based on CAST/Ei. CAST/Ei is the most genetically distant strain within the Mus mus species and many trait variations relevant to common diseases have been identified in CAST/Ei mice. Despite breeding difficulties for some congenic regions, presumably due to incompatible allelic variations between CAST/Ei and C57BL/6, the resulting congenic strains cover about 80% of the autosomal chromosomes and will be useful as a resource for the further analysis of quantitative trait loci between the strains.

A genome-wide set of congenic mouse strains derived from CAST/Ei on a C57BL/6 background. Publishing Authors By Initials

RC Davis,A Jin,M Rosales,S Yu,X Xia,K Ranola,EE Schadt,AJ Lusis,

For similar genetic phenomena: variation (genetics) research abstracts see: genetic phenomena: variation (genetics) research

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A genome-wide set of congenic mouse strains derived from CAST/Ei on a C57BL/6 background. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Genomics

VOLUME: 90

Page Numbers: 306-13

Journal Abbreviation: Genomics

ISSN: 0888-7543

DAY: 27

MONTH: 06

YEAR: 2007

A genome-wide set of congenic mouse strains derived from CAST/Ei on a C57BL/6 background. Information

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LANGUAGE: eng

NlmUniqueID: 8800135

A genome-wide set of congenic mouse strains derived from CAST/Ei on a C57BL/6 background. Keywords Mesh Terms:

KEYWORDS: Variation (Genetics)

MESH TERMS: genetics

Chemical & Substance for Abstract: A genome-wide set of congenic mouse strains derived from CAST/Ei on a C57BL/6 background. Information

Substance Name: DNA

Registry Number: 9007-49-2

Grant and Affiliation Information for A genome-wide set of congenic mouse strains derived from CAST/Ei on a C57BL/6 background.

AFFILIATION: Department of Microbiology, Immunology and Molecular Genetics, University of California at Los Angeles, Los Angeles, CA 90095-1679, USA. davisr@ucla.edu

Country: United States

AGENCY: United States NHLBI

GRANT: HL70526

ACRONYM: HL

MEDLINETA: Genomics

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