A genome-wide search for linkage to renal function phenotypes in West Africans with type 2 diabetes.

A genome-wide search for linkage to renal function phenotypes in West Africans with type 2 diabetes. Research Abstract Details 

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A genome-wide search for linkage to renal function phenotypes in West Africans with type 2 diabetes. Abstract Text:

Guanjie Chen,Adebowale A Adeyemo,Jie Zhou,Yuanxiu Chen,Ayo Doumatey,Kerrie Lashley,Hanxia Huang,Albert Amoah,Kofi Agyenim-Boateng,Benjamin A Eghan,Godfrey Okafor,Joseph Acheampong,Johnnie Oli,Olufemi Fasanmade,Thomas Johnson,Charles Rotimi,

BACKGROUND: Reduced renal function often is a major consequence of diabetes and hypertension. Although several indices of renal function (eg, creatinine clearance) are clearly heritable and show linkage to several genomic regions, the specific underlying genetic determinants are still being sought. The purpose of this study is to conduct a genome-wide search for regions linked to 3 renal function phenotypes, serum creatinine, creatinine clearance, and glomerular filtration rate (GFR), in persons with type 2 diabetes. METHODS: A genome-wide panel of 372 autosomal short tandem repeat markers at an average spacing of 9 centimorgan were typed in 691 patients with type 2 diabetes (321 sib pairs and 36 half-sib pairs) in an affected sib pair study in West Africa. Linkage analysis was conducted with the 3 phenotypes by using a multipoint variance components linkage method. RESULTS: Creatinine clearance showed higher logarithm of odds (LOD) score than the other 2 phenotypes. Linkage to creatinine clearance was observed on chromosomes 16 (marker D16S539, LOD score of 3.56, empirical P = 0.0001), 17 (D17S1298, LOD score of 2.08, empirical P = 0.0018), and 7 (D7S1818, LOD score of 1.84, nominal P = 0.00181, empirical P = 0.0022). Maximum LOD scores for serum creatinine were observed on chromosomes 10 (D10S1432, LOD score of 2.53, empirical P = 0.0001) and 3 (D3S2418, LOD score of 2.21, empirical P = 0.0003) and for GFR on chromosomes 6 (D6S1040, LOD score of 2.08, empirical P = 0.0001) and 8 (D8S256, LOD score of 1.80, empirical P = 0.0001). Several of these results are replications of significant findings from other genome scans. CONCLUSION: A genome-wide scan for serum creatinine, creatinine clearance, and GFR in a West African sample showed linkage regions that may harbor genes influencing variation in these phenotypes. Potential candidate genes in these regions that have been implicated in diabetic nephropathy and/or renal damage in models of hypertension include CYBA (or P22PHOX) (16q24), NOX1 (10q22), and NOX3 (6q25.1-q26).

A genome-wide search for linkage to renal function phenotypes in West Africans with type 2 diabetes. Publishing Authors By Initials

G Chen,AA Adeyemo,J Zhou,Y Chen,A Doumatey,K Lashley,H Huang,A Amoah,K Agyenim-Boateng,BA Eghan,G Okafor,J Acheampong,J Oli,O Fasanmade,T Johnson,C Rotimi,

For similar genetic phenomena: phenotype research abstracts see: genetic phenomena: phenotype research

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A genome-wide search for linkage to renal function phenotypes in West Africans with type 2 diabetes. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: American journal of kidney diseases : the official

VOLUME: 49

Page Numbers: 394-400

Journal Abbreviation: Am. J. Kidney Dis.

ISSN: 1523-6838

DAY: 3

MONTH: Mar

YEAR: 2007

A genome-wide search for linkage to renal function phenotypes in West Africans with type 2 diabetes. Information

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LANGUAGE: eng

NlmUniqueID: 8110075

A genome-wide search for linkage to renal function phenotypes in West Africans with type 2 diabetes. Keywords Mesh Terms:

KEYWORDS: Phenotype

MESH TERMS: genetics

Chemical & Substance for Abstract: A genome-wide search for linkage to renal function phenotypes in West Africans with type 2 diabetes. Information

Substance Name: NADPH Oxidase

Registry Number: EC 1.6.3.1

Grant and Affiliation Information for A genome-wide search for linkage to renal function phenotypes in West Africans with type 2 diabetes.

AFFILIATION: National Human Genome Center at Howard University, College of Medicine, Washington, DC 20059, USA. gchen@howard.edu

Country: United States

AGENCY: United States NHGRI

GRANT: N01-HG-65403

ACRONYM: HG

MEDLINETA: Am J Kidney Dis

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