A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder.

A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder. Research Abstract Details 

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A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder. Abstract Text:

A E Baum,N Akula,M Cabanero,I Cardona,W Corona,B Klemens,T G Schulze,S Cichon,M Rietschel,M M ,A Georgi,J Schumacher,M Schwarz,R Abou Jamra,S ,P Propping,J Satagopan,S D Detera-Wadleigh,J Hardy,F J McMahon,

The genetic basis of bipolar disorder has long been thought to be complex, with the potential involvement of multiple genes, but methods to analyze populations with respect to this complexity have only recently become available. We have carried out a genome-wide association study of bipolar disorder by genotyping over 550 000 single-nucleotide polymorphisms (SNPs) in two independent case-control samples of European origin. The initial association screen was performed using pooled DNA, and selected SNPs were confirmed by individual genotyping. While DNA pooling reduces power to detect genetic associations, there is a substantial cost saving and gain in efficiency. A total of 88 SNPs, representing 80 different genes, met the prior criteria for replication in both samples. Effect sizes were modest: no single SNP of large effect was detected. Of 37 SNPs selected for individual genotyping, the strongest association signal was detected at a marker within the first intron of diacylglycerol kinase eta (DGKH; P=1.5 x 10(-8), experiment-wide P<0.01, OR=1.59). This gene encodes DGKH, a key protein in the lithium-sensitive phosphatidyl inositol pathway. This first genome-wide association study of bipolar disorder shows that several genes, each of modest effect, reproducibly influence disease risk. Bipolar disorder may be a polygenic disease.Molecular Psychiatry (2008) 13, 197-207; doi:10.1038/sj.mp.4002012; published online 8 May 2007.

A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder. Publishing Authors By Initials

AE Baum,N Akula,M Cabanero,I Cardona,W Corona,B Klemens,TG Schulze,S Cichon,M Rietschel,MM ,A Georgi,J Schumacher,M Schwarz,R Abou Jamra,S ,P Propping,J Satagopan,SD Detera-Wadleigh,J Hardy,FJ McMahon,

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A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Molecular psychiatry

VOLUME: 13

Page Numbers: 197-207

Journal Abbreviation: Mol. Psychiatry

ISSN: 1359-4184

DAY: 8

MONTH: 05

YEAR: 2007

A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder. Information

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LANGUAGE: eng

NlmUniqueID: 9607835

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AFFILIATION: 1Unit on the Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Disorders Program, US Department of Health and Human Services, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.

Country: England

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MEDLINETA: Mol Psychiatry

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