A genetic study of Plasmodium susceptibility in the African malaria vector Anopheles gambiae.

A genetic study of Plasmodium susceptibility in the African malaria vector Anopheles gambiae. Research Abstract Details 

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A genetic study of Plasmodium susceptibility in the African malaria vector Anopheles gambiae. Abstract Text:

F H Collins,S M Paskewitz,A E Crews-Oyen,

We are studying the interaction between malarial parasites and their mosquito hosts by a process based on the genetic selection of lines of the mosquito vector that will not support normal parasite development. The model system we are using is the mosquito Anopheles gambiae and a number of different human and non-human primate malarial parasites. Our first effort in this general approach involved the selection of a strain of An. gambiae that was able to encapsulate the malarial parasite during or just after its penetration of the mosquito midgut. This mosquito has been found to be highly refractory to a wide variety of different Plasmodium species and at least partially refractory to all four human malarial parasites. The basis of this phenomenon appears to be the mosquito's enhanced ability to mount a normal encapsulation response against invading pathogens or parasites. The late ookinete is enclosed in a heavily melanized capsule approximately 16-24 hours after the mosquito takes an infective blood meal. Encapsulation appears to be primarily humoral; electron microscopy reveals evidence of the phenomenon as the ookinete passes through or between midgut cells, and no hemocyte involvement has been observed. Subcellular structures in newly encapsulated parasites appear normal, indicating that live rather than dead or dying parasites are encapsulated. Preliminary studies suggest that two unlinked loci contribute to the refractory mosquito phenotype. One of these loci is very closely linked to a region of the mosquito genome that includes two esterases.(ABSTRACT TRUNCATED AT 250 WORDS)

A genetic study of Plasmodium susceptibility in the African malaria vector Anopheles gambiae. Publishing Authors By Initials

FH Collins,SM Paskewitz,AE Crews-Oyen,

For similar genetic processes: selection (genetics) research abstracts see: genetic processes: selection (genetics) research

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A genetic study of Plasmodium susceptibility in the African malaria vector Anopheles gambiae. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Annales de la Société belge de médecine tropicale

VOLUME: 71 Suppl 1

Page Numbers: 225-32

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ISSN: 0772-4128

DAY: 20

MONTH: 02

YEAR: 1991

A genetic study of Plasmodium susceptibility in the African malaria vector Anopheles gambiae. Information

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LANGUAGE: eng

NlmUniqueID: 7511864

A genetic study of Plasmodium susceptibility in the African malaria vector Anopheles gambiae. Keywords Mesh Terms:

KEYWORDS: Selection (Genetics)

MESH TERMS: physiology

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Grant and Affiliation Information for A genetic study of Plasmodium susceptibility in the African malaria vector Anopheles gambiae.

AFFILIATION: Division of Parasitic Diseases, Centers for Disease Control, Atlanta, GA 30333.

Country: BELGIUM

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MEDLINETA: Ann Soc Belg Med Trop

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