A genetic-demographic approach reveals male-specific association between survival and tumor necrosis factor (a/g)-308 polymorphism.

A genetic-demographic approach reveals male-specific association between survival and tumor necrosis factor (a/g)-308 polymorphism. Research Abstract Details 

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A genetic-demographic approach reveals male-specific association between survival and tumor necrosis factor (a/g)-308 polymorphism. Abstract Text:

The (A/G)-308 polymorphism of the tumor necrosis factor alpha gene (TNF) is associated with age-related diseases, but its influence on longevity is controversial. We genotyped for this polymorphism 747 Italian volunteers (401 women and 346 men, age 19-110 years). By applying a genetic-demographic (GD) approach we found that, in men, the survival function of allele A carriers is lower than that of noncarriers at all the ages (p =.044). After defining (by exploiting again demographic information) three age classes, we found that the frequency of men carrying the A allele decreases with age (p =.019), thus confirming the GD analysis results. The same analyses gave negative results in women. Therefore, allele A has a detrimental effect on life expectancy, and this effect is specific to men. A haplotype analysis carried out in men by screening the TNFa, TNFc, and TNFe microsatellite polymorphisms (spanning about 20 kb) confirmed the association of the TNF region with life expectancy.

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A genetic-demographic approach reveals male-specific association between survival and tumor necrosis factor (a/g)-308 polymorphism. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The journals of gerontology. Series A, Biological

VOLUME: 63

Page Numbers: 454-60

Journal Abbreviation: J. Gerontol. A Biol. Sci. Med.

ISSN: 1079-5006

DAY: 30

MONTH: May

YEAR: 2008

A genetic-demographic approach reveals male-specific association between survival and tumor necrosis factor (a/g)-308 polymorphism. Information

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LANGUAGE: eng

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AFFILIATION: Department of Gerontological Research, Italian National Research Center on Aging (I.N.R.C.A), Via Birarelli 8, 60100 Ancona, Italy. maucard@libero.it.

Country: United States

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