A genetic basis for the interrelation of coagulation factors.

A genetic basis for the interrelation of coagulation factors. Research Abstract Details 

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A genetic basis for the interrelation of coagulation factors. Abstract Text:

C Y Vossen,P W Callas,S J Hasstedt,G L Long,F R Rosendaal,E G Bovill,

BACKGROUND: Evidence found in the literature for a strong correlation between coagulation factors suggests that single genes might influence the plasma concentrations of multiple coagulation factors (i.e. pleiotropically acting genes). OBJECTIVE: To determine whether there is a genetic basis for the correlation among coagulation factors by assessing the heritability of interrelated coagulation factors. PATIENTS/METHODS: We performed principal components analysis, and subsequently variance components analysis, to estimate the heritability of principal components of coagulation factors in family members of a large French-Canadian kindred. RESULTS: Four clusters were identified by principal components analysis in 200 family members who did not carry the protein C 3363C mutation. Cluster 1 consisted of prothrombin, factor VII (FVII), FIX, FX and protein S; cluster 2 consisted of FV, FIX, protein C and tissue factor pathway inhibitor; cluster 3 consisted of FVIII and von Willebrand factor; and cluster 4 consisted of antithrombin, protein C and FVII. The heritability of the principal components estimated by variance components analysis was, respectively, 37%, 100%, 37%, and 37%. CONCLUSION: Our findings support the hypothesis that genes can influence plasma levels of interrelated coagulation factors.

A genetic basis for the interrelation of coagulation factors. Publishing Authors By Initials

CY Vossen,PW Callas,SJ Hasstedt,GL Long,FR Rosendaal,EG Bovill,

For similar diagnosis: diagnostic techniques and procedures: diagnostic techniques, radioisotope: radioimmunoassay research abstracts see: diagnosis: diagnostic techniques and procedures: diagnostic techniques, radioisotope: radioimmunoassay research

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A genetic basis for the interrelation of coagulation factors. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of thrombosis and haemostasis : JTH

VOLUME: 5

Page Numbers: 1930-5

Journal Abbreviation: J. Thromb. Haemost.

ISSN: 1538-7933

DAY: 3

MONTH: Sep

YEAR: 2007

A genetic basis for the interrelation of coagulation factors. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101170508

A genetic basis for the interrelation of coagulation factors. Keywords Mesh Terms:

KEYWORDS: Radioimmunoassay

MESH TERMS: genetics

Chemical & Substance for Abstract: A genetic basis for the interrelation of coagulation factors. Information

Substance Name: Prothrombin

Registry Number: 9001-26-7

Grant and Affiliation Information for A genetic basis for the interrelation of coagulation factors.

AFFILIATION: Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands.

Country: England

AGENCY: United States NHLBI

GRANT: HL46703

ACRONYM: HL

MEDLINETA: J Thromb Haemost

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