A gene cluster that regulates both heterocyst differentiation and pattern formation in Anabaena sp. strain PCC 7120.

A gene cluster that regulates both heterocyst differentiation and pattern formation in Anabaena sp. strain PCC 7120. Research Abstract Details 

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A gene cluster that regulates both heterocyst differentiation and pattern formation in Anabaena sp. strain PCC 7120. Abstract Text:

Wei Zhang,Ye Du,Ivan Khudyakov,Qing Fan,Hong Gao,Degang Ning,C Peter Wolk,Xudong Xu,Wei Zhang,Ye Du,Ivan Khudyakov,Qing Fan,Hong Gao,Degang Ning,C Peter Wolk,Xudong Xu,

Wild-type Anabaena sp. strain PCC 7120, a filamentous nitrogen-fixing cyanobacterium, produces single heterocysts at semi-regular intervals. asr0100 (patU5) and alr0101 (patU3) are homologous to the 5' and 3' portions of patU of Nostoc punctiforme. alr0099 (hetZ) overlaps the 5' end of patU5. hetZ, patU5 and patU3 were all upregulated, or expressed specifically, in proheterocysts and heterocysts. Mutants of hetZ showed delayed or no heterocyst differentiation. In contrast, a patU3 mutation produced a multiple contiguous heterocyst (Mch) phenotype and restored the formation of otherwise lost intercalary heterocysts in a patA background. Decreasing the expression of patU3 greatly increased the frequency of heterocysts in a mini-patS strain. Two promoter regions and two principal, corresponding transcripts were detected in the hetZ-patU5-patU3 region. Transcription of hetZ was upregulated in a hetZ mutant and downregulated in a patU3 mutant. When mutants hetZ::C.K2 and hetZ::Tn5-1087b were nitrogen-deprived, P(hetC)-gfp was very weakly expressed, and in hetZ::Tn5-1087b, P(hetR)-gfp was relatively strongly expressed in cells that had neither a regular pattern nor altered morphology. We conclude that the hetZ-patU5-patU3 cluster plays an important role in co-ordination of heterocyst differentiation and pattern formation. The presence of homologous clusters in filamentous genera without heterocysts is suggestive of a more general role.

A gene cluster that regulates both heterocyst differentiation and pattern formation in Anabaena sp. strain PCC 7120. Publishing Authors By Initials

W Zhang,Y Du,I Khudyakov,Q Fan,H Gao,D Ning,CP Wolk,X Xu,W Zhang,Y Du,I Khudyakov,Q Fan,H Gao,D Ning,CP Wolk,X Xu,

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A gene cluster that regulates both heterocyst differentiation and pattern formation in Anabaena sp. strain PCC 7120. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Molecular microbiology

VOLUME: 66

Page Numbers: 1429-43

Journal Abbreviation: Mol. Microbiol.

ISSN: 0950-382X

DAY: 29

MONTH: Dec

YEAR: 2007

A gene cluster that regulates both heterocyst differentiation and pattern formation in Anabaena sp. strain PCC 7120. Information

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LANGUAGE: eng

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Grant and Affiliation Information for A gene cluster that regulates both heterocyst differentiation and pattern formation in Anabaena sp. strain PCC 7120.

AFFILIATION: The State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei 430072, China.

Country: England

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MEDLINETA: Mol Microbiol

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