A 'GAG' reflex prevents repair of the damaged CNS.

A 'GAG' reflex prevents repair of the damaged CNS. Research Abstract Details 

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A 'GAG' reflex prevents repair of the damaged CNS. Abstract Text:

Larry S Sherman,Stephen A Back,

The extracellular matrix of the central nervous system (CNS) serves as both a supporting structure for cells and a rich source of signaling molecules that can influence cell proliferation, survival, migration and differentiation. A large proportion of this matrix is composed of proteoglycans-proteins with long chains of polysaccharides, called glycosaminoglycans (GAGs), covalently attached. Although many of the activities of proteoglycans depend on their core proteins, GAGs themselves can influence cell signaling. Here we review accumulating evidence that two GAGs, chondroitin sulfate and hyaluronan, play essential roles during nervous system development but also accumulate in chronic CNS lesions and inhibit axonal regeneration and remyelination, making them significant hindrances to CNS repair. We propose that the balance between the synthesis and degradation of these molecules dictates, in part, how regeneration and recovery from CNS damage occurs.

A 'GAG' reflex prevents repair of the damaged CNS. Publishing Authors By Initials

LS Sherman,SA Back,

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A 'GAG' reflex prevents repair of the damaged CNS. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Trends in neurosciences

VOLUME: 31

Page Numbers: 44-52

Journal Abbreviation: Trends Neurosci.

ISSN: 0166-2236

DAY: 3

MONTH: 12

YEAR: 2007

A 'GAG' reflex prevents repair of the damaged CNS. Information

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LANGUAGE: eng

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Grant and Affiliation Information for A 'GAG' reflex prevents repair of the damaged CNS.

AFFILIATION: Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA; Department of Cell and Developmental Biology, Oregon Health & Science University, Portland, OR 97239, USA.

Country: England

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MEDLINETA: Trends Neurosci

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