A functional study of miR-124 in the developing neural tube.

A functional study of miR-124 in the developing neural tube. Research Abstract Details 

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A functional study of miR-124 in the developing neural tube. Abstract Text:

Xinwei Cao,Samuel L Pfaff,Fred H Gage,

Neural development is a highly orchestrated process that entails precise control of gene expression. Although microRNAs (miRNAs) have been implicated in fine-tuning gene networks, the roles of individual miRNAs in vertebrate neural development have not been studied in vivo. We investigated the function of the most abundant neuronal miRNA, miR-124, during spinal cord development. Neither inhibition nor overexpression of miR-124 significantly altered the acquisition of neuronal fate, suggesting that miR-124 is unlikely to act as a primary determinant of neuronal differentiation. Two endogenous targets of miR-124, laminin gamma 1 and integrin beta1, were identified, both of which are highly expressed by neural progenitors but repressed upon neuronal differentiation. Thus miR-124 appears to ensure that progenitor genes are post-transcriptionally inhibited in neurons.

A functional study of miR-124 in the developing neural tube. Publishing Authors By Initials

X Cao,SL Pfaff,FH Gage,

For similar cells: stem cells research abstracts see: cells: stem cells research

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MEDLINE DATE:

A functional study of miR-124 in the developing neural tube. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Genes & development

VOLUME: 21

Page Numbers: 531-6

Journal Abbreviation: Genes Dev.

ISSN: 0890-9369

DAY: 1

MONTH: Mar

YEAR: 2007

A functional study of miR-124 in the developing neural tube. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8711660

A functional study of miR-124 in the developing neural tube. Keywords Mesh Terms:

KEYWORDS: Stem Cells

MESH TERMS: metabolism

Chemical & Substance for Abstract: A functional study of miR-124 in the developing neural tube. Information

Substance Name: laminin gamma 1

Registry Number: 0

Grant and Affiliation Information for A functional study of miR-124 in the developing neural tube.

AFFILIATION: Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA.

Country: United States

AGENCY: United States NINDS

GRANT: NS052842

ACRONYM: NS

MEDLINETA: Genes Dev

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