A functional approach to transcriptome profiling: linking gene expression patterns to metabolites that matter.

A functional approach to transcriptome profiling: linking gene expression patterns to metabolites that matter. Research Abstract Details 

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A functional approach to transcriptome profiling: linking gene expression patterns to metabolites that matter. Abstract Text:

Cindi A Hoover,Marc Slattery,Adam G Marsh,Cindi A Hoover,Marc Slattery,Adam G Marsh,

Secondary metabolites or natural products have been isolated from many marine organisms. These metabolites often have important bioactive functions; however, very little information is available regarding the biosynthesis and regulation of many secondary metabolites. At a time when use of marine-derived metabolites is rapidly expanding in industry and pharmacological fields, a better understanding of the genetic mechanisms controlling secondary metabolite production is necessary. We review the recent development of a novel transcriptome profiling methodology that allows for rapid and high-throughput screening of changes in mRNA sequence pools. The application of genomics-based techniques and the integration of both biochemical and molecular data sets in marine organisms complement ongoing drug discovery efforts.

A functional approach to transcriptome profiling: linking gene expression patterns to metabolites that matter. Publishing Authors By Initials

CA Hoover,M Slattery,AG Marsh,CA Hoover,M Slattery,AG Marsh,

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A functional approach to transcriptome profiling: linking gene expression patterns to metabolites that matter. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Marine biotechnology (New York, N.Y.)

VOLUME: 9

Page Numbers: 411-9

Journal Abbreviation: Mar. Biotechnol.

ISSN: 1436-2228

DAY: 1

MONTH: 05

YEAR: 2007

A functional approach to transcriptome profiling: linking gene expression patterns to metabolites that matter. Information

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LANGUAGE: eng

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Grant and Affiliation Information for A functional approach to transcriptome profiling: linking gene expression patterns to metabolites that matter.

AFFILIATION: Molecular Biology Production Group, Broad Institute of MIT and Harvard, Cambridge, MA 02141, USA. cahoov@broad.mit.edu

Country: United States

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MEDLINETA: Mar Biotechnol (NY)

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