A fingerprint left by cytomegalovirus infection in the human T cell compartment.

A fingerprint left by cytomegalovirus infection in the human T cell compartment. Research Abstract Details 

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A fingerprint left by cytomegalovirus infection in the human T cell compartment. Abstract Text:

Pablo J E J van de Berg,Amber van Stijn,Ineke J M Ten Berge,René A W van Lier,

Latent infection with human cytomegalovirus (HCMV) is accompanied by a strong increase in the number of resting, effector-type CD4(+) and CD8(+) T cells with constitutive cytolytic activity in the circulation. Longitudinal studies in kidney transplant recipients revealed that effector cells emerge early after the initial viral burst and acquire their stable phenotype in the months following primary infection. Although it is yet unsettled whether these cells are all specific for CMV encoded or induced antigens, it has become clear that T cell responses to CMV are among the broadest and strongest analyzed so far. We will here summarize the qualities of the effector-type cells found in HCMV carriers and discuss their possible role in CMV-associated pathologies.

A fingerprint left by cytomegalovirus infection in the human T cell compartment. Publishing Authors By Initials

PJ van de Berg,A van Stijn,IJ Ten Berge,RA van Lier,

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A fingerprint left by cytomegalovirus infection in the human T cell compartment. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of clinical virology : the official public

VOLUME: 41

Page Numbers: 213-7

Journal Abbreviation: J. Clin. Virol.

ISSN: 1386-6532

DAY: 3

MONTH: 12

YEAR: 2007

A fingerprint left by cytomegalovirus infection in the human T cell compartment. Information

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LANGUAGE: eng

NlmUniqueID: 9815671

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Grant and Affiliation Information for A fingerprint left by cytomegalovirus infection in the human T cell compartment.

AFFILIATION: Renal Transplant Unit, Academic Medical Centre, Amsterdam, The Netherlands; Department of Experimental Immunology, Academic Medical Centre, Meiberdreef 15, 1105 AZ Amsterdam, The Netherlands.

Country: Netherlands

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MEDLINETA: J Clin Virol

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