A fibrotic focus is a prognostic factor and a surrogate marker for hypoxia and (lymph)angiogenesis in breast cancer: review of the literature and proposal on the criteria of evaluation.

A fibrotic focus is a prognostic factor and a surrogate marker for hypoxia and (lymph)angiogenesis in breast cancer: review of the literature and proposal on the criteria of evaluation. Research Abstract Details 

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A fibrotic focus is a prognostic factor and a surrogate marker for hypoxia and (lymph)angiogenesis in breast cancer: review of the literature and proposal on the criteria of evaluation. Abstract Text:

G G Van den Eynden,C G Colpaert,A Couvelard,F Pezzella,L Y Dirix,P B Vermeulen,E A Van Marck,T Hasebe,G G Van den Eynden,C G Colpaert,A Couvelard,F Pezzella,L Y Dirix,P B Vermeulen,E A Van Marck,T Hasebe,

A fibrotic focus is a scar-like area in the centre of a carcinoma and can be regarded as a focus of exaggerated reactive tumour stroma formation. Although modern surgical pathology uses different histopathological and molecular markers to assess the aggressiveness and predict the behaviour of malignant tumours, markers reflecting stromal cell behaviour and interactions between epithelial cells and stromal cells are scarce. In this review we summarize all studies investigating the value of a fibrotic focus as a prognostic factor and as a surrogate marker for hypoxia and (lymph)angiogenesis in patients with breast cancer. These data show that a fibrotic focus can be used as a practical, easily assessable and reproducible integrative histological prognostic parameter in breast cancer. We propose a consensus methodology to assess the fibrotic focus in breast cancer.

A fibrotic focus is a prognostic factor and a surrogate marker for hypoxia and (lymph)angiogenesis in breast cancer: review of the literature and proposal on the criteria of evaluation. Publishing Authors By Initials

GG Van den Eynden,CG Colpaert,A Couvelard,F Pezzella,LY Dirix,PB Vermeulen,EA Van Marck,T Hasebe,GG Van den Eynden,CG Colpaert,A Couvelard,F Pezzella,LY Dirix,PB Vermeulen,EA Van Marck,T Hasebe,

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A fibrotic focus is a prognostic factor and a surrogate marker for hypoxia and (lymph)angiogenesis in breast cancer: review of the literature and proposal on the criteria of evaluation. Journal Published:

PUBLICATION TYPE: Review

Journal: Histopathology

VOLUME: 51

Page Numbers: 440-51

Journal Abbreviation: Histopathology

ISSN: 0309-0167

DAY: 26

MONTH: 06

YEAR: 2007

A fibrotic focus is a prognostic factor and a surrogate marker for hypoxia and (lymph)angiogenesis in breast cancer: review of the literature and proposal on the criteria of evaluation. Information

Number of References: 62

LANGUAGE: eng

NlmUniqueID: 7704136

A fibrotic focus is a prognostic factor and a surrogate marker for hypoxia and (lymph)angiogenesis in breast cancer: review of the literature and proposal on the criteria of evaluation. Keywords Mesh Terms:

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AFFILIATION: Translational Cancer Research Group (Laboratory Pathology University of Antwerp/University Hospital Antwerp and Oncology Centre, General Hospital St.-Augustinus, Wilrijk), Antwerp, Belgium. gert.van.den.eynden@gza.be

Country: England

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MEDLINETA: Histopathology

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