A fermentation product of phytosterol including campestenone reduces body fat storage and body weight gain in mice.

A fermentation product of phytosterol including campestenone reduces body fat storage and body weight gain in mice. Research Abstract Details 

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A fermentation product of phytosterol including campestenone reduces body fat storage and body weight gain in mice. Abstract Text:

Kunio Suzuki,Rie Konno,Takeshi Shimzu,Tadashi Nagashima,Akihiko Kimura,

Anti-obesity effects of a fermentation product of phytosterols including campestenone in ICR mice were investigated. Five-week-old male ICR mice were fed by the pair-feeding method for 8 wk. Experimental feed was prepared by adding TO-001, a phytostenone mixture produced by fermentation of phytosterols using Nocardioides simplex, at 0.25, 0.5, 1.0, or 2.0% or no additive to a high fat diet (fat 20%). Mice fed a stock feed (fat 5.6%) ad libitum were used as the standard growth group. In animals fed the high fat diet, control (no added TO-001) mice showed a weight gain that was about 10% higher than for the standard growth group. TO-001 reduced body weight dose-dependently. Final body weights of 0.5% and 1.0% TO-001-fed mice were lowered by about 9% and those of 2.0% TO-00 I-fed mice by about 12% compared with the control mice. Visceral and subcutaneous fat weight in mice fed TO-001 was significantly lower than that in mice fed the control diet. The concentrations of serum triglyceride (TG) and total cholesterol (TC) were significantly lower in the 1.0% and/or 2.0% TO-001-fed mice. Furthermore, levels of liver TG and TC were decreased in the TO-001-fed group. Increase of total lipid excretion in the feces was dose dependent. No obvious abnormalities due to consumption of TO-001 were detected by a blood biochemical examination, clinical observations or necropsy. The results suggested that TO-001, a fermentation product of phytosterols, may be a promising component of dietetic functional foods.

A fermentation product of phytosterol including campestenone reduces body fat storage and body weight gain in mice. Publishing Authors By Initials

K Suzuki,R Konno,T Shimzu,T Nagashima,A Kimura,

For similar pathological conditions, signs and symptoms: signs and symptoms: body weight: body weight changes: weight gain research abstracts see: pathological conditions, signs and symptoms: signs and symptoms: body weight: body weight changes: weight gain research

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A fermentation product of phytosterol including campestenone reduces body fat storage and body weight gain in mice. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of nutritional science and vitaminology

VOLUME: 53

Page Numbers: 63-7

Journal Abbreviation:

ISSN: 0301-4800

DAY: 3

MONTH: Feb

YEAR: 2007

A fermentation product of phytosterol including campestenone reduces body fat storage and body weight gain in mice. Information

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LANGUAGE: eng

NlmUniqueID: 402640

A fermentation product of phytosterol including campestenone reduces body fat storage and body weight gain in mice. Keywords Mesh Terms:

KEYWORDS: Weight Gain

MESH TERMS: drug effects

Chemical & Substance for Abstract: A fermentation product of phytosterol including campestenone reduces body fat storage and body weight gain in mice. Information

Substance Name: Cholesterol

Registry Number: 57-88-5

Grant and Affiliation Information for A fermentation product of phytosterol including campestenone reduces body fat storage and body weight gain in mice.

AFFILIATION: Technoflora Co. and Synthetic Organic Chemistry Laboratory, RIKEN, Wako, Saitama 351-0198, Japan. ksuzuki@riken.jp

Country: Japan

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MEDLINETA: J Nutr Sci Vitaminol (Tokyo)

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