A feline immunodeficiency virus vif-deletion mutant remains attenuated upon infection of newborn kittens.

A feline immunodeficiency virus vif-deletion mutant remains attenuated upon infection of newborn kittens. Research Abstract Details 

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A feline immunodeficiency virus vif-deletion mutant remains attenuated upon infection of newborn kittens. Abstract Text:

Xiaoying Shen,Christian M Leutenegger,Kelly Stefano Cole,Niels C Pedersen,Ellen E Sparger,

This report characterizes lentivirus attenuation associated with a vif mutation by inoculation of newborn kittens with a vif-deleted feline immunodeficiency virus provirus plasmid (FIV-pPPRDeltavif). Virus in peripheral blood, antiviral antibody or CD4 T-cell count alterations were not detected in kittens inoculated with FIV-pPPRDeltavif plasmid, with the exception of one kitten that demonstrated FIV Gag antibody production at 42 weeks after inoculation. In contrast, wild-type FIV-pPPR-infected kittens were viraemic, seropositive and exhibited a decrease in the CD4 T-cell subset in peripheral blood. Interestingly, FIV-specific T-cell proliferative responses detected at 32 and 36 weeks after infection were comparable for both FIV-pPPRDeltavif- and wild-type FIV-pPPR-inoculated kittens and suggested the possibility of a discreet tissue reservoir supporting sustained FIV-pPPRDeltavif expression or replication. Overall, these findings confirmed that the severe virus attenuation for both replication and pathogenicity exhibited by a vif-deleted FIV mutant is similar for both neonatal and adult hosts.

A feline immunodeficiency virus vif-deletion mutant remains attenuated upon infection of newborn kittens. Publishing Authors By Initials

X Shen,CM Leutenegger,K Stefano Cole,NC Pedersen,EE Sparger,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: viral physiology: virus replication research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: viral physiology: virus replication research

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A feline immunodeficiency virus vif-deletion mutant remains attenuated upon infection of newborn kittens. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of general virology

VOLUME: 88

Page Numbers: 2793-9

Journal Abbreviation: J. Gen. Virol.

ISSN: 0022-1317

DAY: 3

MONTH: Oct

YEAR: 2007

A feline immunodeficiency virus vif-deletion mutant remains attenuated upon infection of newborn kittens. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 77340

A feline immunodeficiency virus vif-deletion mutant remains attenuated upon infection of newborn kittens. Keywords Mesh Terms:

KEYWORDS: Virus Replication

MESH TERMS: physiology

Chemical & Substance for Abstract: A feline immunodeficiency virus vif-deletion mutant remains attenuated upon infection of newborn kittens. Information

Substance Name: Gene Products, vif

Registry Number: 0

Grant and Affiliation Information for A feline immunodeficiency virus vif-deletion mutant remains attenuated upon infection of newborn kittens.

AFFILIATION: Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.

Country: England

AGENCY: United States NIAID

GRANT: R01AI40896

ACRONYM: AI

MEDLINETA: J Gen Virol

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