A fate map of Tbx1 expressing cells reveals heterogeneity in the second cardiac field.

A fate map of Tbx1 expressing cells reveals heterogeneity in the second cardiac field. Research Abstract Details 

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A fate map of Tbx1 expressing cells reveals heterogeneity in the second cardiac field. Abstract Text:

Tuong Huynh,Li Chen,Phillip Terrell,Antonio Baldini,

Tbx1 is required for the expansion of second heart field (SHF) cardiac progenitors destined to the outflow tract of the heart. Loss of Tbx1 causes heart defects in humans and mice. We report a novel Tbx1(Cre) knock-in allele that we use to fate map Tbx1-expressing cells during development in conjunction with a reporter and 3D image reconstruction. Tbx1 descendants constitute a mesodermal cell population that surrounds the primitive pharynx and approaches the arterial pole of the heart from lateral and posterior, but not anterior directions. These cells populate most of the outflow tract with the exception of the anterior portion, thus identifying a population of the SHF of distinct origin. Both myocardial and underlying endocardial layers were labeled, suggesting a common origin of these cell types. Finally, we show that Tbx1(Cre)-positive and Tbx1(Cre)-negative cell descendants occupy discrete domains in the outflow tract throughout development.

A fate map of Tbx1 expressing cells reveals heterogeneity in the second cardiac field. Publishing Authors By Initials

T Huynh,L Chen,P Terrell,A Baldini,

For similar proteins: dna-binding proteins: t-box domain proteins research abstracts see: proteins: dna-binding proteins: t-box domain proteins research

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A fate map of Tbx1 expressing cells reveals heterogeneity in the second cardiac field. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Genesis (New York, N.Y. : 2000)

VOLUME: 45

Page Numbers: 470-5

Journal Abbreviation: Genesis

ISSN: 1526-954X

DAY: 3

MONTH: Jul

YEAR: 2007

A fate map of Tbx1 expressing cells reveals heterogeneity in the second cardiac field. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100931242

A fate map of Tbx1 expressing cells reveals heterogeneity in the second cardiac field. Keywords Mesh Terms:

KEYWORDS: T-Box Domain Proteins

MESH TERMS: genetics

Chemical & Substance for Abstract: A fate map of Tbx1 expressing cells reveals heterogeneity in the second cardiac field. Information

Substance Name: Tbx1 protein, mouse

Registry Number: 0

Grant and Affiliation Information for A fate map of Tbx1 expressing cells reveals heterogeneity in the second cardiac field.

AFFILIATION: Institute of Biosciences and Technology, Texas A&M University Health Sciences Center, Houston, Texas 77030, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL064832

ACRONYM: HL

MEDLINETA: Genesis

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