A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development.

A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development. Research Abstract Details 

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A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development. Abstract Text:

Michael Y Choi,Anthony I Romer,Michael Hu,Maina Lepourcelet,Ambili Mechoor,Ayce Yesilaltay,Monty Krieger,Paul A Gray,Ramesh A Shivdasani,

Tissue-restricted transcription factors (TFs), which confer specialized cellular properties, are usually identified through sequence homology or cis-element analysis of lineage-specific genes; conventional modes of mRNA profiling often fail to report non-abundant TF transcripts. We evaluated the dynamic expression during mouse gut organogenesis of 1381 transcripts, covering nearly every known and predicted TF, and documented the expression of approximately 1000 TF genes in gastrointestinal development. Despite distinctive structures and functions, the stomach and intestine exhibit limited differences in TF genes. Among differentially expressed transcripts, a few are virtually restricted to the digestive tract, including Nr2e3, previously regarded as a photoreceptor-specific product. TFs that are enriched in digestive organs commonly serve essential tissue-specific functions, hence justifying a search for other tissue-restricted TFs. Computational data mining and experimental investigation focused interest on a novel homeobox TF, Isx, which appears selectively in gut epithelium and mirrors expression of the intestinal TF Cdx2. Isx-deficient mice carry a specific defect in intestinal gene expression: dysregulation of the high density lipoprotein (HDL) receptor and cholesterol transporter scavenger receptor class B, type I (Scarb1). Thus, integration of developmental gene expression with biological assessment, as described here for TFs, represents a powerful tool to investigate control of tissue differentiation.

A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development. Publishing Authors By Initials

MY Choi,AI Romer,M Hu,M Lepourcelet,A Mechoor,A Yesilaltay,M Krieger,PA Gray,RA Shivdasani,

For similar genetic processes: gene expression: transcription, genetic research abstracts see: genetic processes: gene expression: transcription, genetic research

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A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Development (Cambridge, England)

VOLUME: 133

Page Numbers: 4119-29

Journal Abbreviation: Development

ISSN: 0950-1991

DAY: 13

MONTH: 09

YEAR: 2006

A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development. Information

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LANGUAGE: eng

NlmUniqueID: 8701744

A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development. Keywords Mesh Terms:

KEYWORDS: Transcription, Genetic

MESH TERMS: genetics

Chemical & Substance for Abstract: A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development. Information

Substance Name: Transcription Factors

Registry Number: 0

Grant and Affiliation Information for A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development.

AFFILIATION: Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.

Country: England

AGENCY: United States NIDDK

GRANT: R01DK61139

ACRONYM: DK

MEDLINETA: Development

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