A Drosophila doublesex-related gene, terra, is involved in somitogenesis in vertebrates.

A Drosophila doublesex-related gene, terra, is involved in somitogenesis in vertebrates. Research Abstract Details 

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A Drosophila doublesex-related gene, terra, is involved in somitogenesis in vertebrates. Abstract Text:

A Meng,B Moore,H Tang,B Yuan,S Lin,

The Drosophila doublesex (dsx) gene encodes a transcription factor that mediates sex determination. We describe the characterization of a novel zebrafish zinc-finger gene, terra, which contains a DNA binding domain similar to that of the Drosophila dsx gene. However, unlike dsx, terra is transiently expressed in the presomitic mesoderm and newly formed somites. Expression of terra in presomitic mesoderm is restricted to cells that lack expression of MyoD. In vivo, terra expression is reduced by hedgehog but enhanced by BMP signals. Overexpression of terra induces rapid apoptosis both in vitro and in vivo, suggesting that a tight regulation of terra expression is required during embryogenesis. Terra has both human and mouse homologs and is specifically expressed in mouse somites. Taken together, our findings suggest that terra is a highly conserved protein that plays specific roles in early somitogenesis of vertebrates.

A Drosophila doublesex-related gene, terra, is involved in somitogenesis in vertebrates. Publishing Authors By Initials

A Meng,B Moore,H Tang,B Yuan,S Lin,

For similar zinc fingers research abstracts see: zinc fingers research

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A Drosophila doublesex-related gene, terra, is involved in somitogenesis in vertebrates. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Development (Cambridge, England)

VOLUME: 126

Page Numbers: 1259-68

Journal Abbreviation: Development

ISSN: 0950-1991

DAY: 19

MONTH: Mar

YEAR: 1999

A Drosophila doublesex-related gene, terra, is involved in somitogenesis in vertebrates. Information

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LANGUAGE: eng

NlmUniqueID: 8701744

A Drosophila doublesex-related gene, terra, is involved in somitogenesis in vertebrates. Keywords Mesh Terms:

KEYWORDS: Zinc Fingers

MESH TERMS: embryology

Chemical & Substance for Abstract: A Drosophila doublesex-related gene, terra, is involved in somitogenesis in vertebrates. Information

Substance Name: doublesex protein, Drosophila

Registry Number: 0

Grant and Affiliation Information for A Drosophila doublesex-related gene, terra, is involved in somitogenesis in vertebrates.

AFFILIATION: Institute of Molecular Medicine and Genetics and Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA 30912, USA.

Country: ENGLAND

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MEDLINETA: Development

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