A double-switch system regulates male courtship behavior in male and female Drosophila melanogaster.

A double-switch system regulates male courtship behavior in male and female Drosophila melanogaster. Research Abstract Details 

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A double-switch system regulates male courtship behavior in male and female Drosophila melanogaster. Abstract Text:

Troy R Shirangi,Barbara J Taylor,Michael McKeown,

Current models describe male-specific fruitless (fruM) as a genetic 'switch' regulating sexual behavior in Drosophila melanogaster, and they postulate that female (F) and male (M) doublesex (dsx) products control body sexual morphology. In contradiction to this simple model, we show that dsx, as well as fruM and non-sex-specific retained (retn), affect both male and female sexual behaviors. In females, both retn and dsxF contribute to female receptivity, and both genes act to repress male-like courtship activity in the presence or absence of fruM. In males, consistent with the opposing functions of dsxM and dsxF, dsxM acts as a positive factor for male courtship. retn also acts counter to fruM in the development of the male-specific muscle of Lawrence. Molecularly, retn seems to regulate sexual behavior via a previously described complex that represses zerknullt. Thus, we show that fru and dsx together act as a 'switch' system regulating behavior in the context of other developmental genes, such as retn.

A double-switch system regulates male courtship behavior in male and female Drosophila melanogaster. Publishing Authors By Initials

TR Shirangi,BJ Taylor,M McKeown,

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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A double-switch system regulates male courtship behavior in male and female Drosophila melanogaster. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Nature genetics

VOLUME: 38

Page Numbers: 1435-9

Journal Abbreviation: Nat. Genet.

ISSN: 1061-4036

DAY: 5

MONTH: 11

YEAR: 2006

A double-switch system regulates male courtship behavior in male and female Drosophila melanogaster. Information

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LANGUAGE: eng

NlmUniqueID: 9216904

A double-switch system regulates male courtship behavior in male and female Drosophila melanogaster. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: genetics

Chemical & Substance for Abstract: A double-switch system regulates male courtship behavior in male and female Drosophila melanogaster. Information

Substance Name: retained protein, Drosophila

Registry Number: 0

Grant and Affiliation Information for A double-switch system regulates male courtship behavior in male and female Drosophila melanogaster.

AFFILIATION: Molecular Biology, Cell Biology, and Biochemistry Department, Brown University, 69 Brown Street, Providence, Rhode Island 02912, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: T32GM007601

ACRONYM: GM

MEDLINETA: Nat Genet

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