A double-blind multicentre study comparing remoxipride, two and three times daily, with haloperidol in schizophrenia.

A double-blind multicentre study comparing remoxipride, two and three times daily, with haloperidol in schizophrenia. Research Abstract Details 

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A double-blind multicentre study comparing remoxipride, two and three times daily, with haloperidol in schizophrenia. Abstract Text:

G Laux,E Klieser,H G Schröder,V Dittmann,B Unterweger,H Schubert,P König,H W Schöny,J Bunse,H Beckmann,

A double-blind multicentre study comparing the efficacy and safety of remoxipride in relation to haloperidol was conducted in 160 inpatients with schizophrenic illness diagnosed according to DSM-III. The study period was 4 weeks. The mean daily dose of remoxipride (whether given twice or three times daily) during the last week of treatment was 395 mg; the corresponding dose of haloperidol was 17 mg per day. No significant difference in therapeutic efficacy was found; Brief Psychiatric Rating Scale (BPRS) median total scores dropped from 41 to 20 (remoxipride twice daily, n = 51), 43 to 20 (remoxipride three times daily, n = 44) 40 to 19 (haloperidol three times daily, n = 48) at last valid rating. According to Clinical Global Impression (CGI) 68% in the remoxipride twice daily, 58% in the three times daily and 60% in the haloperidol group were very much or much improved. Treatment-emergent extrapyramidal checklist symptoms (hypokinesia, rigidity and tremor) were statistically significantly more frequent and more severe during haloperidol than during remoxipride treatment despite a statistically significantly higher concurrent use of anticholinergic drugs in the haloperidol group. Haloperidol treated patients reported more tiredness and drowsiness than remoxipride treated patients. Also, haloperidol treated patients had a significantly higher frequency of extrapyramidal symptoms on 8 out of 10 items of the Simpson and Angus scale.

A double-blind multicentre study comparing remoxipride, two and three times daily, with haloperidol in schizophrenia. Publishing Authors By Initials

G Laux,E Klieser,HG Schröder,V Dittmann,B Unterweger,H Schubert,P König,HW Schöny,J Bunse,H Beckmann,

For similar behavioral disciplines and activities: schizophrenic psychology research abstracts see: behavioral disciplines and activities: schizophrenic psychology research

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A double-blind multicentre study comparing remoxipride, two and three times daily, with haloperidol in schizophrenia. Journal Published:

PUBLICATION TYPE: Multicenter Study

Journal: Acta psychiatrica Scandinavica. Supplementum

VOLUME: 358

Page Numbers: 125-9

Journal Abbreviation:

ISSN: 0065-1591

DAY: 15

MONTH: 02

YEAR: 1990

A double-blind multicentre study comparing remoxipride, two and three times daily, with haloperidol in schizophrenia. Information

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LANGUAGE: eng

NlmUniqueID: 370365

A double-blind multicentre study comparing remoxipride, two and three times daily, with haloperidol in schizophrenia. Keywords Mesh Terms:

KEYWORDS: Schizophrenic Psychology

MESH TERMS: drug therapy

Chemical & Substance for Abstract: A double-blind multicentre study comparing remoxipride, two and three times daily, with haloperidol in schizophrenia. Information

Substance Name: Remoxipride

Registry Number: 80125-14-0

Grant and Affiliation Information for A double-blind multicentre study comparing remoxipride, two and three times daily, with haloperidol in schizophrenia.

AFFILIATION: Department of Psychiatry, University of Würzburg, FRG.

Country: DENMARK

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MEDLINETA: Acta Psychiatr Scand Suppl

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