A double-blind comparative study of remoxipride and haloperidol in acute schizophrenia.

A double-blind comparative study of remoxipride and haloperidol in acute schizophrenia. Research Abstract Details 

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A double-blind comparative study of remoxipride and haloperidol in acute schizophrenia. Abstract Text:

J A den Boer,D P Ravelli,J Huisman,J Ohrvik,W M Verhoeven,H G Westenberg,

Seventy-one patients were entered into a multicentre, double-blind randomized study to compare the efficacy and safety of remoxipride with those of haloperidol in the acute treatment of schizophrenia or schizophreniform disorder. The patients, who were well-matched regarding demographic characteristics, were aged 18-64 years. Four patients in the remoxipride group and 6 in the haloperidol group discontinued treatment prematurely. The mean daily doses during the last week of treatment were 363 mg remoxipride and 9 mg haloperidol. At this time 22% of patients on remoxipride and 66% of those on haloperidol were taking anticholinergics (p less than 0.001). The clinical efficacy was similar in both groups as judged by Present State Examination (PSE) profile and Brief Psychiatric Rating Scale (BPRS) ratings. Several adverse symptoms occurred significantly more frequently during treatment with haloperidol than with remoxipride, particularly where extrapyramidal symptoms were concerned. No clinically relevant changes occurred in the laboratory tests in either group.

A double-blind comparative study of remoxipride and haloperidol in acute schizophrenia. Publishing Authors By Initials

JA den Boer,DP Ravelli,J Huisman,J Ohrvik,WM Verhoeven,HG Westenberg,

For similar behavioral disciplines and activities: schizophrenic psychology research abstracts see: behavioral disciplines and activities: schizophrenic psychology research

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A double-blind comparative study of remoxipride and haloperidol in acute schizophrenia. Journal Published:

PUBLICATION TYPE: Randomized Controlled Trial

Journal: Acta psychiatrica Scandinavica. Supplementum

VOLUME: 358

Page Numbers: 108-10

Journal Abbreviation:

ISSN: 0065-1591

DAY: 15

MONTH: 02

YEAR: 1990

A double-blind comparative study of remoxipride and haloperidol in acute schizophrenia. Information

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LANGUAGE: eng

NlmUniqueID: 370365

A double-blind comparative study of remoxipride and haloperidol in acute schizophrenia. Keywords Mesh Terms:

KEYWORDS: Schizophrenic Psychology

MESH TERMS: drug therapy

Chemical & Substance for Abstract: A double-blind comparative study of remoxipride and haloperidol in acute schizophrenia. Information

Substance Name: Remoxipride

Registry Number: 80125-14-0

Grant and Affiliation Information for A double-blind comparative study of remoxipride and haloperidol in acute schizophrenia.

AFFILIATION: University Hospital, Department of Biological Psychiatry, Utrecht, The Netherlands.

Country: DENMARK

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MEDLINETA: Acta Psychiatr Scand Suppl

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