A dose-finding study with remoxipride in the acute treatment of schizophrenic patients.

A dose-finding study with remoxipride in the acute treatment of schizophrenic patients. Research Abstract Details 

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A dose-finding study with remoxipride in the acute treatment of schizophrenic patients. Abstract Text:

Two hundred and forty-two patients with acute schizophrenia were enrolled in a double-blind, comparative, dose-finding study of a novel antipsychotic, remoxipride. Remoxipride was evaluated in a low (30 to 90 mg), medium (120 to 240 mg) and a high (300 to 600 mg) dose range and compared with a haloperidol (15 to 45 mg), which was administered to a similar group of patients. The results support the antipsychotic effect of remoxipride, with maximum efficacy occurring at daily doses between 120 mg and 600 mg. Side-effects were more frequent at doses of remoxipride over 300 mg. In all groups, remoxipride caused consistently fewer extrapyramidal side-effects than haloperidol. The antipsychotic effect of remoxipride may be derived from specific blockade of dopamine D2 receptors in the mesolimbic tract. The findings also suggest that remoxipride may have a therapeutic effect on negative symptoms of schizophrenia.

A dose-finding study with remoxipride in the acute treatment of schizophrenic patients. Publishing Authors By Initials

For similar behavioral disciplines and activities: schizophrenic psychology research abstracts see: behavioral disciplines and activities: schizophrenic psychology research

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A dose-finding study with remoxipride in the acute treatment of schizophrenic patients. Journal Published:

PUBLICATION TYPE: Randomized Controlled Trial

Journal: Journal of psychiatry & neuroscience : JPN

VOLUME: 17

Page Numbers: 134-45

Journal Abbreviation: J Psychiatry Neurosci

ISSN: 1180-4882

DAY: 6

MONTH: Oct

YEAR: 1992

A dose-finding study with remoxipride in the acute treatment of schizophrenic patients. Information

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LANGUAGE: eng

NlmUniqueID: 9107859

A dose-finding study with remoxipride in the acute treatment of schizophrenic patients. Keywords Mesh Terms:

KEYWORDS: Schizophrenic Psychology

MESH TERMS: drug therapy

Chemical & Substance for Abstract: A dose-finding study with remoxipride in the acute treatment of schizophrenic patients. Information

Substance Name: Remoxipride

Registry Number: 80125-14-0

Grant and Affiliation Information for A dose-finding study with remoxipride in the acute treatment of schizophrenic patients.

AFFILIATION: Royal Ottawa Hospital, University of Ottawa, Ontario.

Country: CANADA

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MEDLINETA: J Psychiatry Neurosci

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