A divergent route to diversity in macromolecules.

A divergent route to diversity in macromolecules. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

A divergent route to diversity in macromolecules. Abstract Text:

Emily Hollink,Eric E Simanek,

[reaction: see text] A synthetic route for obtaining functional group diversity in macromolecules is described. The route relies on the differential reactivity of substituted dichlorotriazines. Treatment of a triamine core with substituted dichlorotriazines cleanly yields tris(monochlorotriazines). Subsequent S(N)Ar reactions with amine nucleophiles bearing the functional group of interest yield diversity. If the substituent on the dichlorotriazine is a protected nucleophile, deprotection of the functionalized core allows for iterative reactions and the synthesis of star, dendritic, and hybrid macromolecules.

A divergent route to diversity in macromolecules. Publishing Authors By Initials

E Hollink,EE Simanek,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: molecular structure research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: molecular structure research

PUBMED ID PMID:

MEDLINE DATE:

A divergent route to diversity in macromolecules. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Organic letters

VOLUME: 8

Page Numbers: 2293-5

Journal Abbreviation: Org. Lett.

ISSN: 1523-7060

DAY: 25

MONTH: May

YEAR: 2006

A divergent route to diversity in macromolecules. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100890393

A divergent route to diversity in macromolecules. Keywords Mesh Terms:

KEYWORDS: Molecular Structure

MESH TERMS: chemistry

Chemical & Substance for Abstract: A divergent route to diversity in macromolecules. Information

Substance Name: Macromolecular Substances

Registry Number: 0

Grant and Affiliation Information for A divergent route to diversity in macromolecules.

AFFILIATION: Department of Chemistry, Texas A&M University, College Station, 77843, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM 65460

ACRONYM: GM

MEDLINETA: Org Lett

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

A divergent route to diversity in macromolecules Related Publications

• A divergent route to diversity in macromolecules.
• Alkaloids and Phenolics of Colchicum cilicicum1,2.
• Alkaloids from Seeds of Iphigenia stellated1.
• Alkaloids of Androcymbium melanthioides var. stricta1.
• Antiinflammatory Activity of Quaternary Benzophenanthridine Alkaloids from Chelidonoum majus*,**.
• Antioxidant status, lipoprotein profile and liver lipids in rats fed on high-cholesterol diet containing currant oil rich in n-3 and n-6 polyunsaturated fatty acids.
• Cytotoxicity of colchicine derivatives in primary cultures of human hepatocytes.
• HPLC analysis of rosmarinic acid in feed enriched with aerial parts of Prunella vulgaris and its metabolites in pig plasma using dual-channel coulometric detection.
• Inhibition of Acetylcholinesterase Activity by some Isoquinoline Alkaloids*,**.
• Inhibition of butyrylcholinesterase activity by some isoquinoline alkaloids.
• Kilogram-scale synthesis of a second-generation dendrimer based on 1,3,5-triazine using green and industrially compatible methods with a single chromatographic step.
• Maca (Lepidium meyenii) and yacon (Smallanthus sonchifolius) in combination with silymarin as food supplements: In vivo safety assessment.
• Macleaya cordata extract and sangrovit genotoxicity. Assessment in vivo.
• Qualitative and quantitative isotachophoretic analysis of some quaternary isoquinoline alkaloids1,2.
• Separation and Quantification of Some Alkaloids from Fumaria parviflora by Capillary Isotachophoresis1.
• Silybin is metabolized by cytochrome P450 2C8 in vitro.
• Synthesis of water-soluble dendrimers based on melamine bearing 16 Paclitaxel groups.
• The role of the size and number of polyethylene glycol chains in the biodistribution and tumor localization of triazine dendrimers.
• Triazine Dendrimers with Orthogonally Protected Amines on the Periphery. Masking Amines with Dde and BOC Groups Provides an Alternative to Carrying Protected Alcohols and Disulfides through an Iterative Synthesis.
• [Elective videothoracoscopy--a tool for prevention of primary spontaneous pneumothorax?]