A disproportionate role for the fornix and mammillary bodies in recall versus recognition memory.

A disproportionate role for the fornix and mammillary bodies in recall versus recognition memory. Research Abstract Details 

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A disproportionate role for the fornix and mammillary bodies in recall versus recognition memory. Abstract Text:

Uncovering the functional relationship between temporal lobe amnesia and diencephalic amnesia depends on determining the role of the fornix, the major interlinking fiber tract. In this study relating fornix volume with memory, we made magnetic resonance imaging-based volume estimates of 13 brain structures in 38 individuals with surgically removed colloid cysts. Fornix status was assessed directly by overall volume and indirectly by mammillary body volume (which atrophies after fornix damage). Mammillary body volume significantly correlated with 13 out of 14 tests of episodic memory recall, but correlated poorly with recognition memory. Furthermore, as the volumes of the left fornix and the left mammillary bodies decreased, the difference between recall and recognition scores increased. No other structure was consistently associated with memory. These findings support models of diencephalic memory mechanisms that require hippocampal inputs for recall, but not for key elements of recognition.

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A disproportionate role for the fornix and mammillary bodies in recall versus recognition memory. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Nature neuroscience

VOLUME: 11

Page Numbers: 834-42

Journal Abbreviation: Nat. Neurosci.

ISSN: 1097-6256

DAY: 15

MONTH: 06

YEAR: 2008

A disproportionate role for the fornix and mammillary bodies in recall versus recognition memory. Information

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LANGUAGE: eng

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Grant and Affiliation Information for A disproportionate role for the fornix and mammillary bodies in recall versus recognition memory.

AFFILIATION: [1] School of Psychological Sciences, Zochonis Building, University of Manchester, Brunswick Street, Manchester, M13 9PL, UK. [2] These authors contributed equally to this work.

Country: United States

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MEDLINETA: Nat Neurosci

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