A digital atlas to characterize the mouse brain transcriptome.

A digital atlas to characterize the mouse brain transcriptome. Research Abstract Details 

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A digital atlas to characterize the mouse brain transcriptome. Abstract Text:

James P Carson,Tao Ju,Hui-Chen Lu,Christina Thaller,Mei Xu,Sarah L Pallas,Michael C Crair,Joe Warren,Wah Chiu,Gregor Eichele,

Massive amounts of data are being generated in an effort to represent for the brain the expression of all genes at cellular resolution. Critical to exploiting this effort is the ability to place these data into a common frame of reference. Here we have developed a computational method for annotating gene expression patterns in the context of a digital atlas to facilitate custom user queries and comparisons of this type of data. This procedure has been applied to 200 genes in the postnatal mouse brain. As an illustration of utility, we identify candidate genes that may be related to Parkinson disease by using the expression of a dopamine transporter in the substantia nigra as a search query pattern. In addition, we discover that transcription factor Rorb is down-regulated in the barrelless mutant relative to control mice by quantitative comparison of expression patterns in layer IV somatosensory cortex. The semi-automated annotation method developed here is applicable to a broad spectrum of complex tissues and data modalities.

A digital atlas to characterize the mouse brain transcriptome. Publishing Authors By Initials

JP Carson,T Ju,HC Lu,C Thaller,M Xu,SL Pallas,MC Crair,J Warren,W Chiu,G Eichele,

For similar genetic processes: gene expression: transcription, genetic research abstracts see: genetic processes: gene expression: transcription, genetic research

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A digital atlas to characterize the mouse brain transcriptome. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: PLoS computational biology

VOLUME: 1

Page Numbers: e41

Journal Abbreviation: PLoS Comput. Biol.

ISSN: 1553-7358

DAY: 23

MONTH: 09

YEAR: 2005

A digital atlas to characterize the mouse brain transcriptome. Information

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LANGUAGE: eng

NlmUniqueID: 101238922

A digital atlas to characterize the mouse brain transcriptome. Keywords Mesh Terms:

KEYWORDS: Transcription, Genetic

MESH TERMS: genetics

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Grant and Affiliation Information for A digital atlas to characterize the mouse brain transcriptome.

AFFILIATION: Program in Structural and Computational Biology and Molecular Biophysics, National Center for Macromolecular Imaging, Baylor College of Medicine, Houston, Texas, United States of America. james.carson@bcm.edu

Country: United States

AGENCY: United States NIMH

GRANT: R01 MH62639

ACRONYM: MH

MEDLINETA: PLoS Comput Biol

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