A differential screen for putative targets of the bHLH transcription factor Hand1 in cardiac morphogenesis.

A differential screen for putative targets of the bHLH transcription factor Hand1 in cardiac morphogenesis. Research Abstract Details 

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A differential screen for putative targets of the bHLH transcription factor Hand1 in cardiac morphogenesis. Abstract Text:

Nicola Smart,Alison A Hill,James C Cross,Paul R Riley,

The bHLH transcription factor, Hand1 has been implicated in cardiac looping in the mouse, however its function in the developing heart remains unknown. To investigate the mechanism(s) through which Hand1 might function, we screened for potential downstream target genes using representational difference analysis. Thymosin beta4 was found to be down-regulated whereas cystatin C and alphaCA were up-regulated in Hand1-null embryoid bodies. Whole-mount in situ hybridisation on wild type embryos (E8.0-E10.5) and Hand1 homozygous-mutant embryos (E8.0) confirmed co-expression of the putative targets with Hand1 in the heart and their aberrant expression in a Hand1-null background.

A differential screen for putative targets of the bHLH transcription factor Hand1 in cardiac morphogenesis. Publishing Authors By Initials

N Smart,AA Hill,JC Cross,PR Riley,

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A differential screen for putative targets of the bHLH transcription factor Hand1 in cardiac morphogenesis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Mechanisms of development

VOLUME: 119 Suppl 1

Page Numbers: S65-71

Journal Abbreviation: Mech. Dev.

ISSN: 0925-4773

DAY: 30

MONTH: Dec

YEAR: 2002

A differential screen for putative targets of the bHLH transcription factor Hand1 in cardiac morphogenesis. Information

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LANGUAGE: eng

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Grant and Affiliation Information for A differential screen for putative targets of the bHLH transcription factor Hand1 in cardiac morphogenesis.

AFFILIATION: Molecular Medicine Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.

Country: Ireland

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MEDLINETA: Mech Dev

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