A detailed predictive model of the mammalian circadian clock.

A detailed predictive model of the mammalian circadian clock. Research Abstract Details 

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A detailed predictive model of the mammalian circadian clock. Abstract Text:

Daniel B Forger,Charles S Peskin,

Experimental data on the circadian (approximately 24-h) clock in mammalian cells are vast, diverse, and detailed. Mathematical models are therefore needed to piece these data together and to study overall clock behavior. Previous models have focused on Neurospora or Drosophila or can be converted to a Drosophila model simply by renaming variables. Those models used Hill-type terms for transcription regulation and Michaelis-Menten type or delay terms for posttranslation regulation. Recent mammalian experimental data call into question some of the assumptions in these approaches. Moreover, gene duplication has led to more proteins in the mammalian system than in lower organisms. Here we develop a detailed distinctly mammalian model by using mass action kinetics. Parameters for our model are found from experimental data by using a coordinate search method. The model accurately predicts the phase of entrainment, amplitude of oscillation, and shape of time profiles of clock mRNAs and proteins and is also robust to parameter changes and mutations.

A detailed predictive model of the mammalian circadian clock. Publishing Authors By Initials

DB Forger,CS Peskin,

For similar genetic processes: gene expression: transcription, genetic research abstracts see: genetic processes: gene expression: transcription, genetic research

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A detailed predictive model of the mammalian circadian clock. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 100

Page Numbers: 14806-11

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 1

MONTH: 12

YEAR: 2003

A detailed predictive model of the mammalian circadian clock. Information

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LANGUAGE: eng

NlmUniqueID: 7505876

A detailed predictive model of the mammalian circadian clock. Keywords Mesh Terms:

KEYWORDS: Transcription, Genetic

MESH TERMS: metabolism

Chemical & Substance for Abstract: A detailed predictive model of the mammalian circadian clock. Information

Substance Name: cryptochrome protein, Drosophila

Registry Number: 0

Grant and Affiliation Information for A detailed predictive model of the mammalian circadian clock.

AFFILIATION: Courant Institute, New York University, New York, NY 10012, USA. forger@post.harvard.edu

Country: United States

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MEDLINETA: Proc Natl Acad Sci U S A

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