A description of the preterm fetal sheep systemic and central responses to maternal general anesthesia.

A description of the preterm fetal sheep systemic and central responses to maternal general anesthesia. Research Abstract Details 

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A description of the preterm fetal sheep systemic and central responses to maternal general anesthesia. Abstract Text:

Rebecca J McClaine,Kenichiro Uemura,Deborah J McClaine,Kazufumi Shimazutsu,Sebastian G de la Fuente,Roberto J Manson,William D White,William S Eubanks,Paul B Benni,James D Reynolds,

BACKGROUND: The second trimester is recommended as the optimal time to conduct a surgical procedure on pregnant patients, even though the fetal responses to anesthesia at this age are not known. Here we assessed the responses of preterm fetal sheep to a standard anesthetic regimen of midazolam, thiopental, and isoflurane. METHODS: Variables were monitored in previously instrumented preterm pregnant sheep before, during, and after 4 h of general anesthesia. Isoflurane produced moderate fetal hypotension and bradycardia, whereas extubation was accompanied by increases in fetal heart rate and mean arterial blood pressure. RESULTS: We observed an initial increase in fetal Sao2 followed by a gradual decline to baseline. Within the fetal brain, oxygenated hemoglobin changed by <10% (nonsignificant) and deoxygenated hemoglobin and total hemoglobin varied by <5%. Overall, although O2 levels within the preterm fetal brain were not independently enhanced by isoflurane (as occurs in the older fetus and in the adult), they did remain constant even as fetal mean arterial pressure decreased by more than 20%. By extension, we failed to identify changes in cerebral oxygenation that could be construed as injurious. CONCLUSION: Any adverse preterm fetal response to maternal surgery should not be attributed solely to the actions of general anesthesia upon the fetus.

A description of the preterm fetal sheep systemic and central responses to maternal general anesthesia. Publishing Authors By Initials

RJ McClaine,K Uemura,DJ McClaine,K Shimazutsu,SG de la Fuente,RJ Manson,WD White,WS Eubanks,PB Benni,JD Reynolds,

For similar animals: chordata: vertebrates: mammals: artiodactyla: ruminants: sheep research abstracts see: animals: chordata: vertebrates: mammals: artiodactyla: ruminants: sheep research

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MEDLINE DATE:

A description of the preterm fetal sheep systemic and central responses to maternal general anesthesia. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Anesthesia and analgesia

VOLUME: 104

Page Numbers: 397-406

Journal Abbreviation: Anesth. Analg.

ISSN: 1526-7598

DAY: 3

MONTH: Feb

YEAR: 2007

A description of the preterm fetal sheep systemic and central responses to maternal general anesthesia. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 1310650

A description of the preterm fetal sheep systemic and central responses to maternal general anesthesia. Keywords Mesh Terms:

KEYWORDS: Sheep

MESH TERMS: physiology

Chemical & Substance for Abstract: A description of the preterm fetal sheep systemic and central responses to maternal general anesthesia. Information

Substance Name: Isoflurane

Registry Number: 26675-46-7

Grant and Affiliation Information for A description of the preterm fetal sheep systemic and central responses to maternal general anesthesia.

AFFILIATION: Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA.

Country: United States

AGENCY: United States NINDS

GRANT: NS 042664

ACRONYM: NS

MEDLINETA: Anesth Analg

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