A defective beta-hydroxylation of dopamine may precede the full development of hypertension in spontaneously hypertensive rats.

A defective beta-hydroxylation of dopamine may precede the full development of hypertension in spontaneously hypertensive rats. Research Abstract Details 

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A defective beta-hydroxylation of dopamine may precede the full development of hypertension in spontaneously hypertensive rats. Abstract Text:

O Kuchel,K Racz,W Debinski,N T Buu,

A possible mechanism of the previously observed increased adrenal dopamine release and tissue content in spontaneously hypertensive rats (SHR) was explored. The following changes in dopamine beta-hydroxylase activity and catecholamines were noted. At age four weeks (normotensive) or 12 weeks (hypertensive), SHR had lower dopamine beta-hydroxylase activity in the adrenals, heart ventricle and spleen than Wistar Kyoto rats. Tissue dopamine beta-hydroxylase activity in Wistar Kyoto rats was increased with age in the atria but decreased in the ventricles and did not change in the spleen. SHR also had reduced right heart atrial dopamine beta-hydroxylase activity in the hypertensive stage and an overall increase in atrial dopamine content even in the prehypertensive state compared to Wistar Kyoto rats. The increase in noradrenaline content seen with age in the right atrium and spleen in Wistar Kyoto rats was not found in SHR, possibly because of concomitantly decreased dopamine beta-hydroxylase activity. An augmented dopamine:noradrenaline ratio in the spleen of hypertensive SHR may also have been related to an abnormality of the synthesis of noradrenaline from dopamine not necessarily reflected by tissue dopamine beta-hydroxylase determination. A defect of beta-hydroxylation, partly attributable to deficient dopamine beta-hydroxylase activity, may thus precede hypertension and contribute to the hyperdopaminergic state found in SHR.

A defective beta-hydroxylation of dopamine may precede the full development of hypertension in spontaneously hypertensive rats. Publishing Authors By Initials

O Kuchel,K Racz,W Debinski,NT Buu,

For similar tissues: lymphoid tissue: spleen research abstracts see: tissues: lymphoid tissue: spleen research

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A defective beta-hydroxylation of dopamine may precede the full development of hypertension in spontaneously hypertensive rats. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Canadian journal of cardiology

VOLUME: 5

Page Numbers: 327-31

Journal Abbreviation:

ISSN: 1916-7075

DAY: 3

MONTH: Sep

YEAR: 1989

A defective beta-hydroxylation of dopamine may precede the full development of hypertension in spontaneously hypertensive rats. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8510280

A defective beta-hydroxylation of dopamine may precede the full development of hypertension in spontaneously hypertensive rats. Keywords Mesh Terms:

KEYWORDS: Spleen

MESH TERMS: metabolism

Chemical & Substance for Abstract: A defective beta-hydroxylation of dopamine may precede the full development of hypertension in spontaneously hypertensive rats. Information

Substance Name: Dopamine beta-Hydroxylase

Registry Number: EC 1.14.17.1

Grant and Affiliation Information for A defective beta-hydroxylation of dopamine may precede the full development of hypertension in spontaneously hypertensive rats.

AFFILIATION: Laboratory of the Autonomic Nervous System, Clinical Research Institute of Montreal, Quebec.

Country: CANADA

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MEDLINETA: Can J Cardiol

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