A dedicated translation factor controls the synthesis of the global regulator Fis.

A dedicated translation factor controls the synthesis of the global regulator Fis. Research Abstract Details 

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A dedicated translation factor controls the synthesis of the global regulator Fis. Abstract Text:

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BipA is a highly conserved protein with global regulatory properties in Escherichia coli. We show here that it functions as a translation factor that is required specifically for the expression of the transcriptional modulator Fis. BipA binds to ribosomes at a site that coincides with that of elongation factor G and has a GTPase activity that is sensitive to high GDP:GTP ratios and stimulated by 70S ribosomes programmed with mRNA and aminoacylated tRNAs. The growth rate-dependent induction of BipA allows the efficient expression of Fis, thereby modulating a range of downstream processes, including DNA metabolism and type III secretion. We propose a model in which BipA destabilizes unusually strong interactions between the 5' untranslated region of fis mRNA and the ribosome. Since BipA spans phylogenetic domains, transcript-selective translational control for the 'fast-track' expression of specific mRNAs may have wider significance.

A dedicated translation factor controls the synthesis of the global regulator Fis. Publishing Authors By Initials

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For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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A dedicated translation factor controls the synthesis of the global regulator Fis. Journal Published:

PUBLICATION TYPE: Retracted Publication

Journal: The EMBO journal

VOLUME: 23

Page Numbers: 3375-85

Journal Abbreviation: EMBO J.

ISSN: 0261-4189

DAY: 5

MONTH: 08

YEAR: 2004

A dedicated translation factor controls the synthesis of the global regulator Fis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8208664

A dedicated translation factor controls the synthesis of the global regulator Fis. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: genetics

Chemical & Substance for Abstract: A dedicated translation factor controls the synthesis of the global regulator Fis. Information

Substance Name: typA protein, E coli

Registry Number: EC 3.6.1.-

Grant and Affiliation Information for A dedicated translation factor controls the synthesis of the global regulator Fis.

AFFILIATION: School of Biological Sciences, University of Southampton, Southampton, UK.

Country: England

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MEDLINETA: EMBO J

REFSOURCE: EMBO J. 2007 Oct 31;26(21):4607

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