A crucial role for tryptophan catabolism at the host/Candida albicans interface.

A crucial role for tryptophan catabolism at the host/Candida albicans interface. Research Abstract Details 

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A crucial role for tryptophan catabolism at the host/Candida albicans interface. Abstract Text:

Silvia Bozza,Francesca Fallarino,Lucia Pitzurra,Teresa Zelante,Claudia Montagnoli,Silvia Bellocchio,Paolo Mosci,Carmine Vacca,Paolo Puccetti,Luigina Romani,

By mediating tryptophan catabolism, the enzyme indoleamine 2,3-dioxygenase (IDO) has a complex role in immunoregulation in infection, pregnancy, autoimmunity, transplantation, and neoplasia. We hypothesized that IDO might affect the outcome of the infection in mice infected with Candida albicans by virtue of its potent regulatory effects on inflammatory and T cell responses. IDO expression was examined in mice challenged with the fungus along with the consequences of its blockade by in vivo treatment with an enzyme inhibitor. We found that IDO activity was induced at sites of infection as well as in dendritic cells and effector neutrophils via IFN-gamma- and CTLA-4-dependent mechanisms. IDO inhibition greatly exacerbated infection and associated inflammatory pathology as a result of deregulated innate and adaptive/regulatory immune responses. However, a role for tryptophan catabolism was also demonstrated in a fungus-autonomous fashion; its blockade in vitro promoted yeast-to-hyphal transition. These results provide novel mechanistic insights into complex events that, occurring at the fungus/pathogen interface, relate to the dynamics of host adaptation to the fungus. The production of IFN-gamma may be squarely placed at this interface, where IDO activation probably exerts a fine control over fungal morphology as well as inflammatory and adaptive antifungal responses.

A crucial role for tryptophan catabolism at the host/Candida albicans interface. Publishing Authors By Initials

S Bozza,F Fallarino,L Pitzurra,T Zelante,C Montagnoli,S Bellocchio,P Mosci,C Vacca,P Puccetti,L Romani,

For similar genetic processes: gene expression regulation: up-regulation research abstracts see: genetic processes: gene expression regulation: up-regulation research

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A crucial role for tryptophan catabolism at the host/Candida albicans interface. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of immunology (Baltimore, Md. : 1950)

VOLUME: 174

Page Numbers: 2910-8

Journal Abbreviation: J. Immunol.

ISSN: 0022-1767

DAY: 1

MONTH: Mar

YEAR: 2005

A crucial role for tryptophan catabolism at the host/Candida albicans interface. Information

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LANGUAGE: eng

NlmUniqueID: 2985117

A crucial role for tryptophan catabolism at the host/Candida albicans interface. Keywords Mesh Terms:

KEYWORDS: Up-Regulation

MESH TERMS: immunology

Chemical & Substance for Abstract: A crucial role for tryptophan catabolism at the host/Candida albicans interface. Information

Substance Name: Indoleamine-Pyrrole 2,3,-Dioxygenase

Registry Number: EC 1.13.11.42

Grant and Affiliation Information for A crucial role for tryptophan catabolism at the host/Candida albicans interface.

AFFILIATION: Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy.

Country: United States

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MEDLINETA: J Immunol

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