A critical role of CD30 ligand/CD30 in controlling inflammatory bowel diseases in mice.

A critical role of CD30 ligand/CD30 in controlling inflammatory bowel diseases in mice. Research Abstract Details 

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A critical role of CD30 ligand/CD30 in controlling inflammatory bowel diseases in mice. Abstract Text:

Xun Sun,Shinichi Somada,Kensuke Shibata,Hiromi Muta,Hisakata Yamada,Hirofumi Yoshihara,Kuniomi Honda,Kazuhiko Nakamura,Ryhoichi Takayanagi,Kenzaburo Tani,Eckhard R Podack,Yasunobu Yoshikai,Xun Sun,Shinichi Somada,Kensuke Shibata,Hiromi Muta,Hisakata Yamada,Hirofumi Yoshihara,Kuniomi Honda,Kazuhiko Nakamura,Ryhoichi Takayanagi,Kenzaburo Tani,Eckhard R Podack,Yasunobu Yoshikai,

BACKGROUND & AIMS: A CD30-ligand (CD30L) is a 40-kilodalton, type II membrane-associated glycoprotein belonging to the tumor necrosis factor family. Serum levels of soluble CD30 increased in inflammatory bowel diseases (IBD), suggesting that CD30L/CD30 signaling is involved in the pathogenesis of IBD. In this study, we investigated the role of CD30L in oxazolone (OXA)- and trinitrobenzene sulfonic acid (TNBS)-induced colitis in CD30L knockout (KO) mice. METHODS: Colitis was induced by OXA or TNBS in CD30LKO mice with BALB/c or C57BL/6 background, respectively, and diverse clinical signs of the disease were evaluated. Cytokine production from lamina propria T cells of the colon was assessed by enzyme-linked immunosorbent assay. Anti-interleukin (IL)-4 monoclonal antibody (mAb) or agonistic anti-CD30 mAb was inoculated in mice with colitis induced by OXA or TNBS. RESULTS: CD30LKO mice were susceptible to OXA-induced colitis but resistant to TNBS-induced acute colitis. The levels of T helper cell 2 type cytokines such as IL-4 and IL-13 in the LP T cells were significantly higher, but the levels of interferon gamma were lower in OXA- or TNBS-treated CD30LKO mice than in wild-type mice. In vivo administration of agonistic anti-CD30 mAb ameliorated OXA-induced colitis but aggravated TNBS-induced colitis in CD30LKO mice. CONCLUSIONS: These results suggest that CD30L/CD30 signaling is involved in development of both OXA- and TNBS-induced colitis. Modulation of CD30L/CD30 signaling by mAb could be a novel biologic therapy for IBD.

A critical role of CD30 ligand/CD30 in controlling inflammatory bowel diseases in mice. Publishing Authors By Initials

X Sun,S Somada,K Shibata,H Muta,H Yamada,H Yoshihara,K Honda,K Nakamura,R Takayanagi,K Tani,ER Podack,Y Yoshikai,X Sun,S Somada,K Shibata,H Muta,H Yamada,H Yoshihara,K Honda,K Nakamura,R Takayanagi,K Tani,ER Podack,Y Yoshikai,

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A critical role of CD30 ligand/CD30 in controlling inflammatory bowel diseases in mice. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Gastroenterology

VOLUME: 134

Page Numbers: 447-58

Journal Abbreviation: Gastroenterology

ISSN: 1528-0012

DAY: 4

MONTH: 11

YEAR: 2007

A critical role of CD30 ligand/CD30 in controlling inflammatory bowel diseases in mice. Information

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LANGUAGE: eng

NlmUniqueID: 374630

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AFFILIATION: Division of Host Defense, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.

Country: United States

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MEDLINETA: Gastroenterology

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