A critical role for neutrophils in resistance to experimental infection with Burkholderia pseudomallei.

A critical role for neutrophils in resistance to experimental infection with Burkholderia pseudomallei. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

A critical role for neutrophils in resistance to experimental infection with Burkholderia pseudomallei. Abstract Text:

Anna Easton,Ashraful Haque,Karen Chu,Roman Lukaszewski,Gregory J Bancroft,

Inhalation is an important route of infection with Burkholderia pseudomallei, the causative agent of melioidosis. In resistant C57BL/6 mice, activated neutrophils are rapidly recruited to the lungs after intranasal B. pseudomallei infection. Prevention of this response by use of the anti-Gr-1+ cell-depleting monoclonal antibody RB6-8C5 severely exacerbated disease, resulting in an acute lethal infection associated with a 1000-fold increase in lung bacterial loads within 4 days. C57BL/6 interferon (IFN)-gamma(-/-) mice were also acutely susceptible to pulmonary B. pseudomallei infection, dying within 3 days of challenge; this suggests that IFN-gamma is essential for control in the lungs and precedes the protective role of neutrophils in resistance. In neutrophil-depleted mice, lung concentrations of tumor necrosis factor (TNF)-alpha, IFN-gamma, and interleukin-6 were decreased by up to 98%. Natural killer cells were the principle source of IFN-gamma, and monocytes were the principle source of TNF-alpha, suggesting that neutrophils play an important indirect role in the generation of the early cytokine environment in the lungs.

A critical role for neutrophils in resistance to experimental infection with Burkholderia pseudomallei. Publishing Authors By Initials

A Easton,A Haque,K Chu,R Lukaszewski,GJ Bancroft,

For similar cells: blood cells: leukocytes: granulocytes: neutrophils research abstracts see: cells: blood cells: leukocytes: granulocytes: neutrophils research

PUBMED ID PMID:

MEDLINE DATE:

A critical role for neutrophils in resistance to experimental infection with Burkholderia pseudomallei. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of infectious diseases

VOLUME: 195

Page Numbers: 99-107

Journal Abbreviation: J. Infect. Dis.

ISSN: 0022-1899

DAY: 21

MONTH: 11

YEAR: 2006

A critical role for neutrophils in resistance to experimental infection with Burkholderia pseudomallei. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 413675

A critical role for neutrophils in resistance to experimental infection with Burkholderia pseudomallei. Keywords Mesh Terms:

KEYWORDS: Neutrophils

MESH TERMS: physiology

Chemical & Substance for Abstract: A critical role for neutrophils in resistance to experimental infection with Burkholderia pseudomallei. Information

Substance Name: Cytokines

Registry Number: 0

Grant and Affiliation Information for A critical role for neutrophils in resistance to experimental infection with Burkholderia pseudomallei.

AFFILIATION: London School of Hygiene and Tropical Medicine, London, WC1E 7HT, United Kingdom.

Country: United States

AGENCY: United States NIAID

GRANT: AI-61363

ACRONYM: AI

MEDLINETA: J Infect Dis

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

A critical role for neutrophils in resistance to experimental infection with Burkholderia pseudomallei Related Publications

• A comparative linkage map of oilseed rape and its use for QTL analysis of seed oil and erucic acid content.
• A critical role for neutrophils in resistance to experimental infection with Burkholderia pseudomallei.
• A live experimental vaccine against Burkholderia pseudomallei elicits CD4+ T cell-mediated immunity, priming T cells specific for 2 type III secretion system proteins.
• Abdominal gas volume at altitude and at ground level. SAM-TR-67-102.
• Comparative cardiovascular responses of baboons and dogs to near-vacuum pressures. SAM-TR-68-44.
• Domperidone plus paracetamol in the treatment of migraine.
• Effect of anoxia and blood transfusions on the production of polycythemia in rabbits.
• Heredity and environment.
• Integration of Brassica A genome genetic linkage map between Brassica napus and B. rapa.
• Lust or identity?
• MR Imaging of Infectious Processes of the Knee.
• MR Imaging of the Diabetic Foot.
• MR Imaging of the Knee: Incidental Osseous Lesions.
• Melting of viral RNA by coat protein: Assembly strategies for elongated plant viruses.
• Neurologic adaptations in mice exposed to a chronic 2 x gravity field. SAM-TR-65-51.
• Outbreak of Typhoid Fever with Orange Juice as the Vehicle, Illustrating the Value of Immunization.
• Psychiatric morbidity and referral on two general medical wards.
• Relationship of venous pressure to intrapulmonic pressure. A comparison of continuous positive-pressure breathing by mask and by helmet.
• Six new recombinant inbred populations for the study of quantitative traits in Arabidopsis thaliana.
• Small animal centrifuge for chronic acceleration studies. SAM-TR-65-23.
• Some cardiovascular responses in anesthetized dogs during repeated decompressions to a near-vacuum. SAM-TR-66-88.
• Subassembly aggregates of papaya mosaic virus protein.
• The architecture of the potexviruses.
• The inhibition of papaya mosaic virus assembly related to the effect of cations on its RNA.
• The polarity of assembly of papaya mosaic virus and tobacco mosaic virus RNAs with PMV-protein under conditions of nonspecificity.
• The prevalence of suspected Barrett's esophagus in children and adolescents: a multicenter endoscopic study.
• The spirit of the researcher.
• The structure of an unusual ordered aggregate of papaya mosaic virus protein.
• Upper Ordovician trilobites of zonal value in south-east Shropshire.
• [In Process Citation]