A critical role for central vasopressin in regulation of fever during bacterial infection.

A critical role for central vasopressin in regulation of fever during bacterial infection. Research Abstract Details 

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A critical role for central vasopressin in regulation of fever during bacterial infection. Abstract Text:

Previous investigations on the antipyretic properties of arginine vasopressin have used bacterial endotoxins or pyrogens to induce fever. Because these experimental models of fever fail to mimic all aspects of the responses to infection, we felt it was important to examine the role of endogenously released vasopressin as a neuromodulator in febrile thermoregulation during infection. Therefore the present study examines the effects of chronic infusion of a V1-receptor antagonist or saline (via osmotic minipumps into the ventral septal area of the brain) on a fever induced by injection of live bacteria. Telemetry was used for continuous measurement of body temperature in the awake unhandled rat. Animals infused with the V1-antagonist exhibited fevers that were greater in duration compared with those of saline-infused animals. These results support the hypothesis that vasopressin functions as an antipyretic agent or fever-reducing agent in brain. Importantly, they suggest that endogenously released vasopressin may play a role as a neuromodulator in natural fever.

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A critical role for central vasopressin in regulation of fever during bacterial infection. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The American journal of physiology

VOLUME: 263

Page Numbers: R1235-40

Journal Abbreviation: Am. J. Physiol.

ISSN: 0002-9513

DAY: 16

MONTH: Dec

YEAR: 1992

A critical role for central vasopressin in regulation of fever during bacterial infection. Information

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LANGUAGE: eng

NlmUniqueID: 370511

A critical role for central vasopressin in regulation of fever during bacterial infection. Keywords Mesh Terms:

KEYWORDS: Vasopressins

MESH TERMS: physiology

Chemical & Substance for Abstract: A critical role for central vasopressin in regulation of fever during bacterial infection. Information

Substance Name: vasopressin, 1-(1-mercaptocyclohexaneace

Registry Number: 73168-24-8

Grant and Affiliation Information for A critical role for central vasopressin in regulation of fever during bacterial infection.

AFFILIATION: Department of Physiology, University of British Columbia, Vancouver, Canada.

Country: UNITED STATES

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MEDLINETA: Am J Physiol

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