A correlation between the secondary structure of DNA and the reactivity of adenine residues with chloroacetaldehyde.

A correlation between the secondary structure of DNA and the reactivity of adenine residues with chloroacetaldehyde. Research Abstract Details 

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A correlation between the secondary structure of DNA and the reactivity of adenine residues with chloroacetaldehyde. Abstract Text:

K Kimura,M Nakanishi,T Yamamoto,M Tsuboi,

The rate of reaction of chloroacetaldehyde (0.039 M) with the "free" adenine residue in deoxyadenosine-5'-phosphate (dAMP) at pH 6.5 has been found to be nearly equal to that at pH 4.5. Practically 100% of the adenine is converted to a fluorescent product (epsilon-adenine residue) on incubation for 60 h at 37 degrees C and pH 6.5. Of the adenine residues in "single-stranded" DNA, however, only 14% react with chloroacetaldehyde (0.039 M) under the same incubation conditions. The reaction rate of this 14% is nearly equal to that of dAMP, but the fluorescence of the product is appreciably quenched; the quantum yield is only 0.45 times that of the "free" adenine residue. In "double-helical" DNA, on the other hand, no adenine residue has been found to react with chloracetaldehyde. Possible application of these findings to structural studies of DNA is suggested.

A correlation between the secondary structure of DNA and the reactivity of adenine residues with chloroacetaldehyde. Publishing Authors By Initials

K Kimura,M Nakanishi,T Yamamoto,M Tsuboi,

For similar environment and public health: environment: environment, controlled: temperature research abstracts see: environment and public health: environment: environment, controlled: temperature research

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A correlation between the secondary structure of DNA and the reactivity of adenine residues with chloroacetaldehyde. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biochemistry

VOLUME: 81

Page Numbers: 1699-703

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Jun

YEAR: 1977

A correlation between the secondary structure of DNA and the reactivity of adenine residues with chloroacetaldehyde. Information

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LANGUAGE: eng

NlmUniqueID: 376600

A correlation between the secondary structure of DNA and the reactivity of adenine residues with chloroacetaldehyde. Keywords Mesh Terms:

KEYWORDS: Temperature

MESH TERMS: analogs & derivatives

Chemical & Substance for Abstract: A correlation between the secondary structure of DNA and the reactivity of adenine residues with chloroacetaldehyde. Information

Substance Name: DNA

Registry Number: 9007-49-2

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Country: JAPAN

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MEDLINETA: J Biochem

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