A correlation between function and selected measures of T cell avidity in influenza virus-specific CD8+ T cell responses.

A correlation between function and selected measures of T cell avidity in influenza virus-specific CD8+ T cell responses. Research Abstract Details 

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A correlation between function and selected measures of T cell avidity in influenza virus-specific CD8+ T cell responses. Abstract Text:

Nicole L La Gruta,Peter C Doherty,Stephen J Turner,

Activation of mature CD8+ T cells requires recognition, via the T cell receptor (TCR), of peptide + MHC (pMHC) complexes with an avidity that exceeds a designated threshold. Multiple indicators of T cell avidity have been described that provide unique information on the characteristics of T cell interactions. However, these indicators are routinely used in isolation, and, consequently, little is known about correlations between these measures or which measure, if any, correlates with the quality of the T cell response. Following influenza virus infection of C57BL/6J mice, we analyzed the relative avidities of five epitope-specific CD8+ T cell populations using five different measures. We demonstrated that the quality of CD8+ T cell responses, in terms of cytokine profiles, correlates with TCR dissociation rate and CD8 dependence, but not with the sensitivity to tetramer binding or peptide stimulation. Thus, we propose that, despite significant differences in TCR dissociation rate, the stimulation threshold of influenza-specific CD8+ T cell populations may be equivalent due to compensatory mechanisms largely provided by the CD8 coreceptor. Furthermore, this study shows that different indicators of avidity do not necessarily provide similar information and should be used in combination to obtain an overall picture of the characteristics of TCR binding.

A correlation between function and selected measures of T cell avidity in influenza virus-specific CD8+ T cell responses. Publishing Authors By Initials

NL La Gruta,PC Doherty,SJ Turner,

For similar proteins: membrane proteins: receptors, cell surface: receptors, immunologic: receptors, antigen: receptors, antigen, t-cell research abstracts see: proteins: membrane proteins: receptors, cell surface: receptors, immunologic: receptors, antigen: receptors, antigen, t-cell research

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A correlation between function and selected measures of T cell avidity in influenza virus-specific CD8+ T cell responses. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: European journal of immunology

VOLUME: 36

Page Numbers: 2951-9

Journal Abbreviation: Eur. J. Immunol.

ISSN: 0014-2980

DAY: 3

MONTH: Nov

YEAR: 2006

A correlation between function and selected measures of T cell avidity in influenza virus-specific CD8+ T cell responses. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 1273201

A correlation between function and selected measures of T cell avidity in influenza virus-specific CD8+ T cell responses. Keywords Mesh Terms:

KEYWORDS: Receptors, Antigen, T-Cell

MESH TERMS: metabolism

Chemical & Substance for Abstract: A correlation between function and selected measures of T cell avidity in influenza virus-specific CD8+ T cell responses. Information

Substance Name: Lymphocyte Specific Protein Tyrosine Kin

Registry Number: EC 2.7.1.37

Grant and Affiliation Information for A correlation between function and selected measures of T cell avidity in influenza virus-specific CD8+ T cell responses.

AFFILIATION: Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia. nllg@unimelb.edu.au

Country: Germany

AGENCY: United States NIAID

GRANT: AI350395

ACRONYM: AI

MEDLINETA: Eur J Immunol

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