A Convenient Synthesis of Substituted Pyrazolidines and Azaproline Derivatives through Highly Regio- and Diastereoselective Reduction of 2-Pyrazolines.

A Convenient Synthesis of Substituted Pyrazolidines and Azaproline Derivatives through Highly Regio- and Diastereoselective Reduction of 2-Pyrazolines. Research Abstract Details 

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A Convenient Synthesis of Substituted Pyrazolidines and Azaproline Derivatives through Highly Regio- and Diastereoselective Reduction of 2-Pyrazolines. Abstract Text:

Santos,Yago ,Domitila Aparicio,Francisco Palacios,Jesús M de Los Santos,Yago López,Domitila Aparicio,Francisco Palacios, de Los Santos,Yago ,Domitila Aparicio,Francisco Palacios,

The synthesis of substituted N-acetyl- and N-aroyl-2-pyrazolines via intramolecular Michael addition of alpha,beta-unsaturated hydrazones generated through olefination of phosphinyl and phosphonyl hydrazones with carbonyl compounds is reported. The regioselective reduction of the C-N double bond in these 2-pyrazolines using Superhydride (Et3BHLi) gives pirazolidine derivatives with excellent levels of cis-diastereoselectivity. These 2-pyrazolines can also be obtained in one-pot reaction from allenes, hydrazides, and aldehydes; and pyrazolidines, after reduction, from allenes, hydrazides, and aldehydes. This synthetic route was developed to provide a new approach to substituted azaproline derivatives in a diastereoselective fashion.

A Convenient Synthesis of Substituted Pyrazolidines and Azaproline Derivatives through Highly Regio- and Diastereoselective Reduction of 2-Pyrazolines. Publishing Authors By Initials

JM Santos,Y ,D Aparicio,F Palacios,JM de Los Santos,Y López,D Aparicio,F Palacios,JM de Los Santos,Y ,D Aparicio,F Palacios,

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A Convenient Synthesis of Substituted Pyrazolidines and Azaproline Derivatives through Highly Regio- and Diastereoselective Reduction of 2-Pyrazolines. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of organic chemistry

VOLUME: 73

Page Numbers: 550-7

Journal Abbreviation: J. Org. Chem.

ISSN: 0022-3263

DAY: 18

MONTH: 12

YEAR: 2007

A Convenient Synthesis of Substituted Pyrazolidines and Azaproline Derivatives through Highly Regio- and Diastereoselective Reduction of 2-Pyrazolines. Information

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LANGUAGE: eng

NlmUniqueID: 2985193

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Grant and Affiliation Information for A Convenient Synthesis of Substituted Pyrazolidines and Azaproline Derivatives through Highly Regio- and Diastereoselective Reduction of 2-Pyrazolines.

AFFILIATION: Departamento de Química OrgAnica I, Facultad de Farmacia, Universidad del País Vasco, Apartado 450, 01080 Vitoria, Spain.

Country: United States

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MEDLINETA: J Org Chem

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