A controlled double-blind study of high-dose dihydroergotoxine mesylate (Hydergine) in mild dementia.

A controlled double-blind study of high-dose dihydroergotoxine mesylate (Hydergine) in mild dementia. Research Abstract Details 

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A controlled double-blind study of high-dose dihydroergotoxine mesylate (Hydergine) in mild dementia. Abstract Text:

In a double-blind study of 41 outpatients aged 55 to 80 years with mild memory impairment, the efficacy of dihydroergotoxine mesylate (DEM, Hydergine) at 6 mg per day, administered orally, was tested during a twelve-week period. Specific etiologies for the amnesic syndrome were ruled out by history, physical examination, and laboratory tests. Subjects with a Hamilton Depression Scale rating above 18, ie, possible pseudodementia, were excluded. Physician rating of memory, employing the Inventory of Psychic and Somatic Complaints in the Elderly (IPSC-E), indicated statistically significant improvement of memory function in DEM treated subjects (N = 22) v those on placebo (N = 19), (F = 3.34; df = 1,39; P less than .04). In contrast, structured testing of recent memory using digit symbol substitution and Zahlenverbindungs test (ZVT) showed improvement in both groups (P less than .001) with no significant intergroup differences (P less than .10). Out results indicate that in cases of mild, though subjectively distressing impairment, DEM at higher dosages may help to enhance short-term memory function.

A controlled double-blind study of high-dose dihydroergotoxine mesylate (Hydergine) in mild dementia. Publishing Authors By Initials

For similar behavioral disciplines and activities: psychiatric status rating scales research abstracts see: behavioral disciplines and activities: psychiatric status rating scales research

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A controlled double-blind study of high-dose dihydroergotoxine mesylate (Hydergine) in mild dementia. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of the American Geriatrics Society

VOLUME: 35

Page Numbers: 219-23

Journal Abbreviation: J Am Geriatr Soc

ISSN: 0002-8614

DAY: 10

MONTH: Mar

YEAR: 1987

A controlled double-blind study of high-dose dihydroergotoxine mesylate (Hydergine) in mild dementia. Information

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LANGUAGE: eng

NlmUniqueID: 7503062

A controlled double-blind study of high-dose dihydroergotoxine mesylate (Hydergine) in mild dementia. Keywords Mesh Terms:

KEYWORDS: Psychiatric Status Rating Scales

MESH TERMS: drug effects

Chemical & Substance for Abstract: A controlled double-blind study of high-dose dihydroergotoxine mesylate (Hydergine) in mild dementia. Information

Substance Name: Dihydroergotoxine

Registry Number: 11032-41-0

Grant and Affiliation Information for A controlled double-blind study of high-dose dihydroergotoxine mesylate (Hydergine) in mild dementia.

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Country: UNITED STATES

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MEDLINETA: J Am Geriatr Soc

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