A contribution to the differential diagnosis of the "group of schizophrenias": structural abnormality of chromosome 4.

A contribution to the differential diagnosis of the "group of schizophrenias": structural abnormality of chromosome 4. Research Abstract Details 

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A contribution to the differential diagnosis of the "group of schizophrenias": structural abnormality of chromosome 4. Abstract Text:

A structural abnormality of chromosome 4 [inv 4 (p15.2; q21.3)] is reported in a male presenting with DSM-III-R schizophrenia, undifferentiated type (295.94) and in his mother, who displayed symptoms associated with schizotypal personality disorder (DSM-III-R 301.22). The proband had a performance IQ of 91, poor motor coordination, stature in the lowest quartile and an impaired sense of time. There were no diagnostic physical or neurological abnormalities. Mild ventricular enlargement and prominent sulci were found on computed tomography. Both he and his chromosomally normal father had strabismus which required surgical correction. This case joins the long list of chromosomal abnormalities previously reported to confer an increased risk of mental illness and emphasizes the importance of a sophisticated differential diagnosis in evaluating patients who present with symptoms of schizophrenia. The implications for recent initiatives which attempt to localize genes conferring susceptibility to schizophrenia and other major mental illnesses are discussed.

A contribution to the differential diagnosis of the "group of schizophrenias": structural abnormality of chromosome 4. Publishing Authors By Initials

For similar behavioral disciplines and activities: schizophrenic psychology research abstracts see: behavioral disciplines and activities: schizophrenic psychology research

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A contribution to the differential diagnosis of the "group of schizophrenias": structural abnormality of chromosome 4. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of psychiatry & neuroscience : JPN

VOLUME: 19

Page Numbers: 270-7

Journal Abbreviation: J Psychiatry Neurosci

ISSN: 1180-4882

DAY: 6

MONTH: Jul

YEAR: 1994

A contribution to the differential diagnosis of the "group of schizophrenias": structural abnormality of chromosome 4. Information

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LANGUAGE: eng

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A contribution to the differential diagnosis of the "group of schizophrenias": structural abnormality of chromosome 4. Keywords Mesh Terms:

KEYWORDS: Schizophrenic Psychology

MESH TERMS: genetics

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Grant and Affiliation Information for A contribution to the differential diagnosis of the "group of schizophrenias": structural abnormality of chromosome 4.

AFFILIATION: Department of Psychiatry, McGill University, Montreal, Quebec.

Country: CANADA

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MEDLINETA: J Psychiatry Neurosci

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