A conserved structural module regulates transcriptional responses to diverse stress signals in bacteria.

A conserved structural module regulates transcriptional responses to diverse stress signals in bacteria. Research Abstract Details 

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A conserved structural module regulates transcriptional responses to diverse stress signals in bacteria. Abstract Text:

Elizabeth A Campbell,Roger Greenwell,Jennifer R Anthony,Sheng Wang,Lionel Lim,Kalyan Das,Heidi J Sofia,Timothy J Donohue,Seth A Darst,Elizabeth A Campbell,Roger Greenwell,Jennifer R Anthony,Sheng Wang,Lionel Lim,Kalyan Das,Heidi J Sofia,Timothy J Donohue,Seth A Darst,

A transcriptional response to singlet oxygen in Rhodobacter sphaeroides is controlled by the group IV sigma factor sigma(E) and its cognate anti-sigma ChrR. Crystal structures of the sigma(E)/ChrR complex reveal a modular, two-domain architecture for ChrR. The ChrR N-terminal anti-sigma domain (ASD) binds a Zn(2+) ion, contacts sigma(E), and is sufficient to inhibit sigma(E)-dependent transcription. The ChrR C-terminal domain adopts a cupin fold, can coordinate an additional Zn(2+), and is required for the transcriptional response to singlet oxygen. Structure-based sequence analyses predict that the ASD defines a common structural fold among predicted group IV anti-sigmas. These ASDs are fused to diverse C-terminal domains that are likely involved in responding to specific environmental signals that control the activity of their cognate sigma factor.

A conserved structural module regulates transcriptional responses to diverse stress signals in bacteria. Publishing Authors By Initials

EA Campbell,R Greenwell,JR Anthony,S Wang,L Lim,K Das,HJ Sofia,TJ Donohue,SA Darst,EA Campbell,R Greenwell,JR Anthony,S Wang,L Lim,K Das,HJ Sofia,TJ Donohue,SA Darst,

For similar inorganic chemicals: elements: metals, heavy: zinc research abstracts see: inorganic chemicals: elements: metals, heavy: zinc research

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A conserved structural module regulates transcriptional responses to diverse stress signals in bacteria. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Molecular cell

VOLUME: 27

Page Numbers: 793-805

Journal Abbreviation: Mol. Cell

ISSN: 1097-2765

DAY: 7

MONTH: Sep

YEAR: 2007

A conserved structural module regulates transcriptional responses to diverse stress signals in bacteria. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9802571

A conserved structural module regulates transcriptional responses to diverse stress signals in bacteria. Keywords Mesh Terms:

KEYWORDS: Zinc

MESH TERMS: metabolism

Chemical & Substance for Abstract: A conserved structural module regulates transcriptional responses to diverse stress signals in bacteria. Information

Substance Name: Oxygen

Registry Number: 7782-44-7

Grant and Affiliation Information for A conserved structural module regulates transcriptional responses to diverse stress signals in bacteria.

AFFILIATION: The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM053759

ACRONYM: GM

MEDLINETA: Mol Cell

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ACCESSION NUMBER: 2Q1Z

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