A conserved motif present in a class of helix-loop-helix proteins activates transcription by direct recruitment of the SAGA complex.

A conserved motif present in a class of helix-loop-helix proteins activates transcription by direct recruitment of the SAGA complex. Research Abstract Details 

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A conserved motif present in a class of helix-loop-helix proteins activates transcription by direct recruitment of the SAGA complex. Abstract Text:

The class I helix-loop-helix (HLH) proteins, which include E2A, HEB, and E2-2, have been shown to be required for lineage-specific gene expression during T and B lymphocyte development. Additionally, the E2A proteins function to regulate V(D)J recombination, possibly by allowing access of variable region segments to the recombination machinery. The mechanisms by which E2A regulates transcription and recombination, however, are largely unknown. Here, we identify a novel motif, LDFS, present in the vertebrate class I HLH proteins as well as in a yeast HLH protein that is essential for transactivation. We provide both genetic and biochemical evidence that the highly conserved LDFS motif stimulates transcription by direct recruitment of the SAGA histone acetyltransferase complex.

A conserved motif present in a class of helix-loop-helix proteins activates transcription by direct recruitment of the SAGA complex. Publishing Authors By Initials

For similar investigative techniques: genetic techniques: gene transfer techniques: transfection research abstracts see: investigative techniques: genetic techniques: gene transfer techniques: transfection research

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A conserved motif present in a class of helix-loop-helix proteins activates transcription by direct recruitment of the SAGA complex. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Molecular cell

VOLUME: 4

Page Numbers: 63-73

Journal Abbreviation: Mol. Cell

ISSN: 1097-2765

DAY: 8

MONTH: Jul

YEAR: 1999

A conserved motif present in a class of helix-loop-helix proteins activates transcription by direct recruitment of the SAGA complex. Information

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LANGUAGE: eng

NlmUniqueID: 9802571

A conserved motif present in a class of helix-loop-helix proteins activates transcription by direct recruitment of the SAGA complex. Keywords Mesh Terms:

KEYWORDS: Transfection

MESH TERMS: genetics

Chemical & Substance for Abstract: A conserved motif present in a class of helix-loop-helix proteins activates transcription by direct recruitment of the SAGA complex. Information

Substance Name: TCF12 protein, human

Registry Number: 142661-93-6

Grant and Affiliation Information for A conserved motif present in a class of helix-loop-helix proteins activates transcription by direct recruitment of the SAGA complex.

AFFILIATION: Department of Biology, University of California, San Diego, La Jolla 92093, USA.

Country: UNITED STATES

AGENCY: United States NIGMS

GRANT: GM47867

ACRONYM: GM

MEDLINETA: Mol Cell

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