A connector of two-component regulatory systems promotes signal amplification and persistence of expression.

A connector of two-component regulatory systems promotes signal amplification and persistence of expression. Research Abstract Details 

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A connector of two-component regulatory systems promotes signal amplification and persistence of expression. Abstract Text:

Akinori Kato,Alexander Y Mitrophanov,Eduardo A Groisman,

Organisms rely on a variety of regulatory architectures to control gene transcription. Whereas the functional characteristics of particular architectures are well understood, the properties of newly discovered regulatory designs cannot be easily predicted. One emerging design depends on small proteins that connect two-component regulatory systems, which constitute the dominant form of bacterial signal transduction. These connectors enable one system to respond to the signal perceived by a different system. To understand the functional properties of such connector-mediated architectures, we investigated the pathway controlled by the PhoP-dependent connector protein PmrD of Salmonella enterica and contrasted it to the circuit in which genes are regulated directly by the transcription factor PhoP. The PmrD-mediated pathway displayed both signal amplification and persistence of expression when compared with the direct pathway. Mathematical modeling of the two pathways allowed us to identify critical factors responsible for signal amplification.

A connector of two-component regulatory systems promotes signal amplification and persistence of expression. Publishing Authors By Initials

A Kato,AY Mitrophanov,EA Groisman,

For similar genetic processes: gene expression: transcription, genetic research abstracts see: genetic processes: gene expression: transcription, genetic research

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A connector of two-component regulatory systems promotes signal amplification and persistence of expression. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 12063-8

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 5

MONTH: 07

YEAR: 2007

A connector of two-component regulatory systems promotes signal amplification and persistence of expression. Information

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LANGUAGE: eng

NlmUniqueID: 7505876

A connector of two-component regulatory systems promotes signal amplification and persistence of expression. Keywords Mesh Terms:

KEYWORDS: Transcription, Genetic

MESH TERMS: drug effects

Chemical & Substance for Abstract: A connector of two-component regulatory systems promotes signal amplification and persistence of expression. Information

Substance Name: Polymyxin B

Registry Number: 1404-26-8

Grant and Affiliation Information for A connector of two-component regulatory systems promotes signal amplification and persistence of expression.

AFFILIATION: Department of Molecular Microbiology, Howard Hughes Medical Institute, Washington University School of Medicine, Campus Box 8230, 660 South Euclid Avenue, St. Louis, MO 63110, USA.

Country: United States

AGENCY: United States PHS

GRANT: 42336

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MEDLINETA: Proc Natl Acad Sci U S A

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