A Conformational Change in the alpha-subunit of Coatomer Induced by Ligand Binding to gamma-COP Revealed by Single-pair FRET.

A Conformational Change in the alpha-subunit of Coatomer Induced by Ligand Binding to gamma-COP Revealed by Single-pair FRET. Research Abstract Details 

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A Conformational Change in the alpha-subunit of Coatomer Induced by Ligand Binding to gamma-COP Revealed by Single-pair FRET. Abstract Text:

Formation of transport vesicles involves polymerization of cytoplasmic coat proteins (COP). In COPI vesicle biogenesis, the heptameric complex coatomer is recruited to donor membranes by the interaction of multiple coatomer subunits with the budding machinery. Specific binding to the trunk domain of gamma-COP by the Golgi membrane protein p23 induces a conformational change that causes polymerization of the complex. Using single-pair fluorescence resonance energy transfer, we find that this conformational change takes place in individual coatomer complexes, independent of each other, and that the conformational rearrangement induced in gamma-COP is transmitted within the complex to its alpha-subunit. We suggest that capture of membrane protein machinery triggers cage formation in the COPI system.

A Conformational Change in the alpha-subunit of Coatomer Induced by Ligand Binding to gamma-COP Revealed by Single-pair FRET. Publishing Authors By Initials

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A Conformational Change in the alpha-subunit of Coatomer Induced by Ligand Binding to gamma-COP Revealed by Single-pair FRET. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Traffic (Copenhagen, Denmark)

VOLUME: 9

Page Numbers: 597-607

Journal Abbreviation: Traffic

ISSN: 1398-9219

DAY: 25

MONTH: 12

YEAR: 2007

A Conformational Change in the alpha-subunit of Coatomer Induced by Ligand Binding to gamma-COP Revealed by Single-pair FRET. Information

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LANGUAGE: eng

NlmUniqueID: 100939340

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Grant and Affiliation Information for A Conformational Change in the alpha-subunit of Coatomer Induced by Ligand Binding to gamma-COP Revealed by Single-pair FRET.

AFFILIATION: Heidelberg University Biochemistry Center, Heidelberg University, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany.

Country: Denmark

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MEDLINETA: Traffic

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