A component based noise correction method (CompCor) for BOLD and perfusion based fMRI.

A component based noise correction method (CompCor) for BOLD and perfusion based fMRI. Research Abstract Details 

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A component based noise correction method (CompCor) for BOLD and perfusion based fMRI. Abstract Text:

Yashar Behzadi,Khaled Restom,Joy Liau,Thomas T Liu,

A component based method (CompCor) for the reduction of noise in both blood oxygenation level-dependent (BOLD) and perfusion-based functional magnetic resonance imaging (fMRI) data is presented. In the proposed method, significant principal components are derived from noise regions-of-interest (ROI) in which the time series data are unlikely to be modulated by neural activity. These components are then included as nuisance parameters within general linear models for BOLD and perfusion-based fMRI time series data. Two approaches for the determination of the noise ROI are considered. The first method uses high-resolution anatomical data to define a region of interest composed primarily of white matter and cerebrospinal fluid, while the second method defines a region based upon the temporal standard deviation of the time series data. With the application of CompCor, the temporal standard deviation of resting-state perfusion and BOLD data in gray matter regions was significantly reduced as compared to either no correction or the application of a previously described retrospective image based correction scheme (RETROICOR). For both functional perfusion and BOLD data, the application of CompCor significantly increased the number of activated voxels as compared to no correction. In addition, for functional BOLD data, there were significantly more activated voxels detected with CompCor as compared to RETROICOR. In comparison to RETROICOR, CompCor has the advantage of not requiring external monitoring of physiological fluctuations.

A component based noise correction method (CompCor) for BOLD and perfusion based fMRI. Publishing Authors By Initials

Y Behzadi,K Restom,J Liau,TT Liu,

For similar psychological phenomena and processes: mental processes: perception: visual perception research abstracts see: psychological phenomena and processes: mental processes: perception: visual perception research

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A component based noise correction method (CompCor) for BOLD and perfusion based fMRI. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: NeuroImage

VOLUME: 37

Page Numbers: 90-101

Journal Abbreviation: Neuroimage

ISSN: 1053-8119

DAY: 3

MONTH: 05

YEAR: 2007

A component based noise correction method (CompCor) for BOLD and perfusion based fMRI. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9215515

A component based noise correction method (CompCor) for BOLD and perfusion based fMRI. Keywords Mesh Terms:

KEYWORDS: Visual Perception

MESH TERMS: physiology

Chemical & Substance for Abstract: A component based noise correction method (CompCor) for BOLD and perfusion based fMRI. Information

Substance Name: Oxygen

Registry Number: 7782-44-7

Grant and Affiliation Information for A component based noise correction method (CompCor) for BOLD and perfusion based fMRI.

AFFILIATION: UCSD Center for Functional Magnetic Resonance Imaging and Department of Radiology, 9500 Gilman Drive, MC 0677, La Jolla, CA 92093-0677, USA.

Country: United States

AGENCY: United States NINDS

GRANT: R01NS051661

ACRONYM: NS

MEDLINETA: Neuroimage

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