A complex plasma plant sterol locus on mouse chromosome 14 has at least two genes regulating intestinal sterol absorption.

A complex plasma plant sterol locus on mouse chromosome 14 has at least two genes regulating intestinal sterol absorption. Research Abstract Details 

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A complex plasma plant sterol locus on mouse chromosome 14 has at least two genes regulating intestinal sterol absorption. Abstract Text:

Ephraim Sehayek,Yee Yan Fung,Hannah J Yu,Jan Lembcke,Uta Ceglarek,Daniel Teupser,Joachim Thiery,Dieter Lutjohann,Klaus von Bergmann,Jan L Breslow,

We previously identified two inbred mouse strains, C57BL/6J and CASA/Rk, with different plasma plant sterol levels. An intercross between these strains revealed a broad plasma plant sterol locus on chromosome 14, which peaked at 17 centimorgan (cM) with a maximum logarithm of the odds score of 9.9. Studies in a chromosome 14 congenic strain, 14KK, with a 4-60 cM CASA/Rk interval on the C57BL/6J background revealed that males, but not females, had decreased plasma plant sterol levels and intestinal cholesterol absorption. In two subcongenic strains, 14PKK and 14DKK, with 4-19.5 and 19.5-60 cM CASA/Rk intervals, respectively, both males and females had decreased plasma plant sterol levels and decreased intestinal cholesterol absorption. Compatible with the decreased plasma plant sterol phenotype, 14PKK mice had increased biliary plant sterol excretion, whereas 14DKK mice did not. Therefore, gender-dependent interactions of genes at the 14PKK and 14DKK intervals are likely to underlie the 14KK interval effect on plasma plant sterol levels and sterol absorption from the intestine. These studies confirm the plasma plant sterol locus on mouse chromosome 14 and provide evidence that there are at least two sets of genes operating: one set affecting intestinal sterol absorption and biliary excretion, and the other set mainly affecting intestinal sterol absorption.

A complex plasma plant sterol locus on mouse chromosome 14 has at least two genes regulating intestinal sterol absorption. Publishing Authors By Initials

E Sehayek,YY Fung,HJ Yu,J Lembcke,U Ceglarek,D Teupser,J Thiery,D Lutjohann,K von Bergmann,JL Breslow,

For similar biological phenomena, cell phenomena, and immunity: immunity: antibody specificity: species specificity research abstracts see: biological phenomena, cell phenomena, and immunity: immunity: antibody specificity: species specificity research

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A complex plasma plant sterol locus on mouse chromosome 14 has at least two genes regulating intestinal sterol absorption. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of lipid research

VOLUME: 47

Page Numbers: 2291-6

Journal Abbreviation: J. Lipid Res.

ISSN: 0022-2275

DAY: 13

MONTH: 07

YEAR: 2006

A complex plasma plant sterol locus on mouse chromosome 14 has at least two genes regulating intestinal sterol absorption. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 376606

A complex plasma plant sterol locus on mouse chromosome 14 has at least two genes regulating intestinal sterol absorption. Keywords Mesh Terms:

KEYWORDS: Species Specificity

MESH TERMS: pharmacokinetics

Chemical & Substance for Abstract: A complex plasma plant sterol locus on mouse chromosome 14 has at least two genes regulating intestinal sterol absorption. Information

Substance Name: Phytosterols

Registry Number: 0

Grant and Affiliation Information for A complex plasma plant sterol locus on mouse chromosome 14 has at least two genes regulating intestinal sterol absorption.

AFFILIATION: Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, NY, USA. sehayee@rockefeller.edu

Country: United States

AGENCY: United States NHLBI

GRANT: HL-032435-22

ACRONYM: HL

MEDLINETA: J Lipid Res

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