A comparison of the production of reactive oxygen species by suspended particulate matter and diesel exhaust particles with macrophages.

A comparison of the production of reactive oxygen species by suspended particulate matter and diesel exhaust particles with macrophages. Research Abstract Details 

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A comparison of the production of reactive oxygen species by suspended particulate matter and diesel exhaust particles with macrophages. Abstract Text:

M Ohyama,T Otake,S Adachi,T Kobayashi,K Morinaga,

Oxidative stress has emerged as a pivotal mechanism that underlies the toxic pulmonary effects of suspended particulate matter (SPM). Experimental evidence shows that redox-active transition metals, redox-cycling quinoids, and polycyclic aromatic hydrocarbons (PAHs) contained in SPM act synergistically, producing reactive oxygen species (ROS). The direct production of superoxide anion and the damaging hydroxyl radical has been studied in aqueous and dimethyl sulfoxide (DMSO) suspensions of SPM both with and without H2O2; however, no study has reported on the release of ROS from ingesting macrophages with SPM. We investigated the time course of the ability to induce lucigenin-dependent chemiluminescence (CL) from human monocyte-derived macrophages exposed to SPM, carbon black particles, and diesel exhaust particles (DEP). We also examined hydroxyl radical generation from the same experimental system using the 2-deoxy-d-robse method. We found an increase of CL for SPM, but not for carbon black particles or for DEP. Hydroxyl radical generation was observed in both SPM and DEP, but the release from DEP was more frequent than that from SPM. These results suggest that certain components of SPM are important in the response of ROS from ingesting macrophages with SPM, and that those components are discharged from SPM into the atmosphere.

A comparison of the production of reactive oxygen species by suspended particulate matter and diesel exhaust particles with macrophages. Publishing Authors By Initials

M Ohyama,T Otake,S Adachi,T Kobayashi,K Morinaga,

For similar complex mixtures: vehicle emissions research abstracts see: complex mixtures: vehicle emissions research

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A comparison of the production of reactive oxygen species by suspended particulate matter and diesel exhaust particles with macrophages. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Inhalation toxicology

VOLUME: 19 Suppl 1

Page Numbers: 157-60

Journal Abbreviation:

ISSN: 1091-7691

DAY: 19

MONTH: 11

YEAR: 2007

A comparison of the production of reactive oxygen species by suspended particulate matter and diesel exhaust particles with macrophages. Information

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LANGUAGE: eng

NlmUniqueID: 8910739

A comparison of the production of reactive oxygen species by suspended particulate matter and diesel exhaust particles with macrophages. Keywords Mesh Terms:

KEYWORDS: Vehicle Emissions

MESH TERMS: metabolism

Chemical & Substance for Abstract: A comparison of the production of reactive oxygen species by suspended particulate matter and diesel exhaust particles with macrophages. Information

Substance Name: Vehicle Emissions

Registry Number: 0

Grant and Affiliation Information for A comparison of the production of reactive oxygen species by suspended particulate matter and diesel exhaust particles with macrophages.

AFFILIATION: Osaka Prefectural Institute of Public Health, Osaka, Japan. ohyama@iph.pref.osaka.jp

Country: United States

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MEDLINETA: Inhal Toxicol

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