A comparison of the immunomodulating properties of two forms of monophosphoryl lipid A analogues.

A comparison of the immunomodulating properties of two forms of monophosphoryl lipid A analogues. Research Abstract Details 

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A comparison of the immunomodulating properties of two forms of monophosphoryl lipid A analogues. Abstract Text:

This investigation compared the immunomodulating activities of two forms monophosphoryl lipid A, which are analogues of bacterial lipopolysaccharides with little or no toxicity. Tested were a synthetic compound designated 504 and a purified compound, isolated from bacterial cell walls designated MPL. Both of these clinical adjuvant candidates were effective in mice in exerting strong immunomodulating activity in the following areas: (a) enhancing antibody production in young and aging mice; (b) suppressing antibody formation under different experimental conditions; (c) activating macrophages to secrete interleukin 1, hydrogen peroxide, and superoxide anion; and (d) stimulating proliferation of spleen cells from C3H/HeN mice. Both exhibited considerably reduced toxicity in LD50 assays when compared to native lipopolysaccharides (LPS). The LD50 for MPL was 225 times and that of compound 504, 40 times that of native LPS in the exquisitely sensitive, galactosamine-loaded C57BL/6 murine strain.

A comparison of the immunomodulating properties of two forms of monophosphoryl lipid A analogues. Publishing Authors By Initials

For similar animals: animal population groups: animals, inbred strains: mice, inbred strains research abstracts see: animals: animal population groups: animals, inbred strains: mice, inbred strains research

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A comparison of the immunomodulating properties of two forms of monophosphoryl lipid A analogues. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of immunotherapy : official journal of the

VOLUME: 10

Page Numbers: 398-404

Journal Abbreviation: J. Immunother.

ISSN: 1053-8550

DAY: 18

MONTH: Dec

YEAR: 1991

A comparison of the immunomodulating properties of two forms of monophosphoryl lipid A analogues. Information

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LANGUAGE: eng

NlmUniqueID: 9102704

A comparison of the immunomodulating properties of two forms of monophosphoryl lipid A analogues. Keywords Mesh Terms:

KEYWORDS: Mice, Inbred Strains

MESH TERMS: drug effects

Chemical & Substance for Abstract: A comparison of the immunomodulating properties of two forms of monophosphoryl lipid A analogues. Information

Substance Name: monophosphoryl lipid A

Registry Number: 0

Grant and Affiliation Information for A comparison of the immunomodulating properties of two forms of monophosphoryl lipid A analogues.

AFFILIATION: Department of Medical Microbiology/Immunology, University of Minnesota, Duluth 55812.

Country: UNITED STATES

AGENCY: United States NIAID

GRANT: AI 25810

ACRONYM: AI

MEDLINETA: J Immunother (1991)

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