A comparison of arteries and veins in oxidative stress: producers, destroyers, function, and disease.

A comparison of arteries and veins in oxidative stress: producers, destroyers, function, and disease. Research Abstract Details 

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A comparison of arteries and veins in oxidative stress: producers, destroyers, function, and disease. Abstract Text:

Theodora Szasz,Keshari Thakali,Gregory D Fink,Stephanie W Watts,

Reactive oxygen species (ROS) are by-products of oxygen metabolism, normally present in low levels inside cells, where they participate in signaling processes. The delicate balance in the continuous cycle of ROS generation and inactivation is maintained by enzymatic and nonenzymatic endogenous systems. Overwhelming production of ROS (by such sources as the mitochondrial electron transport chain, NADPH oxidase, xanthine oxidase, or uncoupled nitric oxide synthase), when inadequately counteracted by destruction through antioxidant systems (such as superoxide dismutase or catalase), leads to a prooxidant state also known as oxidative stress. Increased levels of ROS and markers of oxidative stress have been consistently found in such cardiovascular diseases as atherosclerosis or hypertension, although controversy still exists over the pathophysiological role of oxidative stress in these conditions. ROS can modulate vascular function either by direct oxidative damage or by activating cellular signaling pathways that lead to abnormal contractile, inflammatory, proliferative, or remodeling properties of the blood vessel. Most current research focuses on these processes in arteries, leaving veins, "the other side" of vascular biology, in obscurity. Veins are different structurally and functionally from arteries. Equipped with a smaller smooth muscle layer compared to arteries, but being able to accommodate 70% of the circulating blood volume, veins can modulate cardiovascular homeostasis and contribute significantly to hypertension pathogenesis. Although the reports on the quantitative differences in ROS production in veins compared to arteries had conflicting results, there is a clear qualitative difference in ROS metabolism and utilization between the two vessel types. This review will compare and contrast the current knowledge of ROS metabolism in arteries versus veins in both physiological and pathophysiological conditions. Our understanding of the mechanisms underlying vascular diseases would greatly benefit from a more thorough exploration of the role of veins and venous oxidative stress.

A comparison of arteries and veins in oxidative stress: producers, destroyers, function, and disease. Publishing Authors By Initials

T Szasz,K Thakali,GD Fink,SW Watts,

For similar cardiovascular system: blood vessels: veins research abstracts see: cardiovascular system: blood vessels: veins research

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A comparison of arteries and veins in oxidative stress: producers, destroyers, function, and disease. Journal Published:

PUBLICATION TYPE: Review

Journal: Experimental biology and medicine (Maywood, N.J.)

VOLUME: 232

Page Numbers: 27-37

Journal Abbreviation: Exp. Biol. Med. (Maywood)

ISSN: 1535-3702

DAY: 3

MONTH: Jan

YEAR: 2007

A comparison of arteries and veins in oxidative stress: producers, destroyers, function, and disease. Information

Number of References: 100

LANGUAGE: eng

NlmUniqueID: 100973463

A comparison of arteries and veins in oxidative stress: producers, destroyers, function, and disease. Keywords Mesh Terms:

KEYWORDS: Veins

MESH TERMS: physiopathology

Chemical & Substance for Abstract: A comparison of arteries and veins in oxidative stress: producers, destroyers, function, and disease. Information

Substance Name: Reactive Oxygen Species

Registry Number: 0

Grant and Affiliation Information for A comparison of arteries and veins in oxidative stress: producers, destroyers, function, and disease.

AFFILIATION: Department of Pharmacology and Toxicology, Michigan State University, B445 Life Sciences, East Lansing, MI 48825, USA. szasziri@msu.edu

Country: United States

AGENCY: United States NHLBI

GRANT: HL-70687

ACRONYM: HL

MEDLINETA: Exp Biol Med (Maywood)

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